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ISSN 1405-1699 (Impreso)
Órgano Oficial del Colegio Mexicano de Alergia, Asma e Inmunología Pediátrica y de la Asociación Latinoamericana de Pediatría

1999, Número 5

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Alerg Asma Inmunol Pediatr 1999; 8 (5)


Esteroides inhalados. Farmacología y aplicación clínica

Hernández VT

Idioma: Español
Referencias bibliográficas: 39
Paginas: 139-147
Archivo PDF: 422.57 Kb.


RESUMEN

Los corticosteroides son potentes antiinflamatorios que se han utilizado en el tratamiento de enfermedades respiratorias desde 1950. Aunque su mecanismo de acción en las enfermedades pulmonares no es muy claro, se ha demostrado in vitro, que inducen la producción de lipocortina 1, que facilita la inhibición de la síntesis de fosfolipasa A2, enzima que favorece la movilización del ácido araquidónico de los fosfolípidos de membrana, con esto se disminuye la producción de mediadores como prostaglandinas, tromboxanos y leucotrienos. En cuanto a su forma de administración, contamos con 3 dispositivos: inhalador de dosis medida, nebulizador e inhalador presurizado. Los esteroides se han utilizado en enfermedades como el asma, croup, bronquiolitis, fibrosis quística, etc. El presente artículo de revisión resume los mecanismos de acción de los esteroides, forma de administración, enfermedades en que se han utilizado y los efectos secundarios que se pueden presentar con su uso.


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