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Medicina Universitaria

2008, Número 39

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Med Univer 2008; 10 (39)


Tratamiento combinado COPP-EBV seguido de radioterapia a dosis baja en 100 niños con linfoma de Hodgkin

Insausti CL, García R, Acquatella G, Pereira A, Rojas N, Páez A

Idioma: Español
Referencias bibliográficas: 36
Paginas: 63-74
Archivo PDF: 274.73 Kb.


RESUMEN

Objetivo: evaluar los resultados de la eficacia y del protocolo COPP-EBV con radioterapia a dosis bajas en niños con linfoma de Hodgkin tratados en 13 centros de Venezuela.
Pacientes y métodos: de enero de 2000 a enero de 2007, el Grupo Cooperativo Hemato-Oncológico Multidisciplinario Pediátrico venezolano trató a 100 niños con linfoma de Hodgkin con promedio de 11.5 años de edad, relación masculino-femenino 1.9:1. Los factores pronóstico fueron: género masculino 66%; estadios clínicos IIB, IIIB, IV A o B 56%; masa mediastinal › 30% (MMV) 17%; GB › 13.5 × 109/L 8%; Hb ‹11 g/dL 28%. Grupo favorable: ‹ 3 factores pronóstico: 42%; grupo desfavorable: › 3 factores pronóstico o estadio clínico IV o MMV 58%. De acuerdo con el estadio clínico y factores pronóstico se clasificaron en tres grupos.
Resultados: grupo total: 88% remisión completa, 7% progresión, 5% recaídas, 10% mortalidad. Grupo 1: 80% supervivencia libre de eventos, 86% supervivencia total. Grupo 2: 68% supervivencia libre de eventos, 85% supervivencia total. Grupo 3: 70% supervivencia libre de eventos, 85% supervivencia total.
Conclusiones: el esquema COPP-EBV asociado con dosis bajas de radioterapia produjo resultados comparables a los reportados en la bibliografía en estadios favorables, no así en los desfavorables, donde las combinaciones de quimioterapia tienen mayor efectividad.


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