Forsmark CE, Baillie J

Idioma: Español
Referencias bibliográficas: 191
Paginas: 257-281
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FRAGMENTO

La pancreatitis aguda continúa siendo una enfermedad caracterizada por una morbilidad y mortalidad significativa, con diversos reportes que señalan un incremento anual de la incidencia de la enfermedad. Artículos de posición sobre la práctica clínica, como éste, están diseñados para educar y guiar a los médicos en la toma de decisiones de atención de pacientes. Estos lineamientos intentan resumir la mejor información disponible y describir la mejor práctica clínica. Es conveniente referir que este abordaje es algo limitado en el área de pancreatitis aguda, debido a la falta de ensayos grandes aleatorizados controlados. Lineamientos como éste, en ausencia de este tipo de evidencia científica de apoyo, debe incluir una buena cantidad de recomendaciones basadas en evidencia menos sólida, incluyendo la opinión de los expertos. Es ciertamente posible que futuros ensayos aleatorizados grandes puedan dar lugar a cambios en los lineamientos similares a éste que están por escribirse. La pancreatitis aguda es una enfermedad de tal variabilidad que no puede ser manejada de manera efectiva siguiendo ciegamente cualquier conjunto de recomendaciones, y estos lineamientos no tienen la intención de ser equivalentes al estándar legal de manejo. En vez de ello, se espera que este artículo de posición pueda combinar los estudios científicos disponibles y la base de evidencia (o la falta de ella) con opinión experta para formar una herramienta útil para los clínicos.

REFERENCIAS (EN ESTE ARTÍCULO)

1. Lowenfels AB, Sullivan T, Fiorianti J, Maisonneuve P. The epidemiology and impact of pancreatic diseases in the United States. Curr Gastroenterol Rep 2005; 7: 90-5.

2. Corfield AP, Cooper MJ, Williamson RC. Acute pancreatitis; a lethal disease of increasing incidence. Gut 1985; 26: 724-9.

3. Wilson C, Imire CW, Carter DC. Fatal acute pancreatitis. Gut 1988; 29: 782-8.

4. Lankisch PG, Schirren CA, Kunze E. Undetected fatal acute pancreatitis: why is the disease so frequently overlooked? Am J Gastroenterol 1991; 86: 322-6.

5. Kemppainen EA, Hedstrom JI, Puolakkainen PA, Sainio VS, et al. Rapid measurement of urinary trypsinogen-2 as a screening test for acute pancreatitis. N Engl J Med 1997; 337: 1394-5.

6. Gumaste VV, Roditis N, Mehta D, Dave PB. Serum lipase levels in nonpancreatic abdominal pain versus acute pancreatitis. Am J Gastroenterol 1993; 88: 2051-5.

7. Treacy J, Williams A, Bais R, Willson K, Worthley C, Reece J, Bessell J, Thomas D. Evaluation of amylase and lipase in the diagnosis of acute pancreatitis. ANZ J Surg 2001; 71: 577-82.

8. Gwozdz GP, Steinberg WM, Werner M, Henry JP, Pauley C. Comparative evaluation of the diagnosis of acute pancreatitis based on serum and urine enzyme assays. Clin Chim Acta 1990; 187: 243-54.

9. Kylanpaa-Back ML, Kemppainen E, Puolakkaninen P, Hedstrom J, Haapiainen R, Korvuo A, Stenman UH. Comparison of urine trypsinogen-2 test strip with serum lipase in the diagnosis of acute pancreatitis. Hepatogastroenterology 2002; 49: 1130-4.

10. Steinberg WM, Goldstein SS, Davis ND, Shamma’a J, Anderson K. Diagnostic assays in acute pancreatitis. A study of sensitivity and specificity. Ann Intern Med 1985; 102: 576-80.

11. Sternby B, O’Brien JF, Zinsmeister AR, DiMagno EP. What is the best biochemical test to diagnose acute pancreatitis? A prospective clinical study. Mayo Clin Proc 1996; 71: 1138-44.

12. Seno T, Harada H, Ochi K, Tanaka J, Matsumoto S, Choudhury R, Mizushima T, Tsuboi K, Ishida M. Serum levels of six pancreatic enzymes as related to the degree of renal dysfunction. Am J Gastroenterol 1995; 90: 2002-5.

13. Yadav D, Agarwal N, Pitchumoni CS. A critical evaluation of laboratory tests in acute pancreatitis. Am J Gastroenterol 2002; 97: 1309-18.

14. Wang SS, Lin XZ, Tsai YT, Lee SD, Pan HB, Chou YH, Su CH, Lee CH, Shiesh SC, Lin CY, et al. Clinical significance of ultrasonography, computed tomography, and biochemical tests in the rapid diagnosis of gallstone-related pancreatitis: a prospective study. Pancreas 1988; 3: 153-8.

15. Neoptolemos JP, Hall AW, Finlay DF, Berry JM, Carr-Locke DL, Fossard DP. The urgent diagnosis of gallstones in acute pancreatitis: a prospective study of three methods. Br J Surg 1984; 71: 230-3.

16. Balthazar EJ. CT diagnosis and staging of acute pancreatitis. Radiol Clin North Am 1989; 27: 19-37.

17. Balthazar EJ. Acute pancreatitis: assessment of severity with clinical and CT evaluation. Radiology 2002; 223: 603-13.

18. Kalra MK, Maher MM, Sahani DV, Digmurthy S, Saini S. Current status of imaging in pancreatic diseases. Comput Assist Tomogr 2002; 26: 661-75.

19. Foitzik T, Bassi DG, Schmidt J, Lewandrowski KB, Fernandez-del Castillo C, Rattner DW, Warshaw AL. Intravenous contrast medium accentuates the severity of acute necrotizing pancreatitis in the rat. Gastroenterology 1994; 106: 207-14.

20. Balthazar EJ, Freeny PC. Contrast-enhanced computed tomography in acute pancreatitis: is it beneficial or harmful? Gastroenterology 1994; 106: 259-62.

21. Hwang TL, Chang KY, Ho YP. Contrast-enhanced dynamic computed tomography does not aggravate the clinical severity of patients with severe acute pancreatitis: reevaluation of the effect of intravenous contrast medium on the severity of acute pancreatitis. Arch Surg 2000; 135: 287-90.

22. Plock JA, Schmidt J, Anderson SE, Sarr MG, Roggo A. Contrastenhanced computed tomography in acute pancreatitis: does contrast medium worsen its course due to impaired microcirculation? Langenbecks Arch Surg 2005; 390: 156-63.

23. Pamuklar E, Semelka RC. MR imaging of the pancreas. Magn Reson Imaging Clin North Am 2005; 13: 313-30.

24. Matos C, Bali MA, Delhaye M, Deviere J. Magnetic resonance imaging in the detection of pancreatitis and pancreatic neoplasms. Best Pract Res Clin Gastroenterol 2006; 20: 157-78.

25. Arvanitakis M, Delhaye M, De Maertelaere V, Bali M, Winant C, Coppens E, Jeanmart J, Zalcman M, Van Gansbeke D, Deviere J, Matos C. Computed tomography and magnetic resonance imaging in the assessment of acute pancreatitis. Gastroenterology 2004; 126: 715-23.

26. Russo MW, Wei JT, Thiny MT, Gangarosa LM, Brown A, Ringel Y, Shaheen NJ, Sandler RS. Digestive and liver diseases statistics, 2004. Gastroenterology 2004; 126: 1448-53.

27. Talamini G, Bassi C, Falconi M, Sartori N, Frulloni L, Di Francesco V, Vesentini S, Pederzoli P, Cavallini G. Risk of death from acute pancreatitis. Role of early, simple “routine” data. Int J Pancreatol 1996; 19: 15-24.

28. Mann DV, Hershman MJ, Hittinger R, Glazer G. Multicentre audit of death from acute pancreatitis. Br J Surg 1994; 81: 890-3.

29. Carnovale A, Rabitti PG, Manes G, Esposito P, Pacelli L, Uomo G. Mortality in acute pancreatitis: is it an early or late event? JOP 2005; 6: 438-44.

30. McKay CJ, Evans S, Sinclair M, Carter CR, Imrie CW. High early mortality rate from acute pancreatitis in Scotland, 1984-1995. Br J Surg 1999; 86: 1302-5.

31. Gloor B, Muller CA, Worni M, Martignoni ME, Uhl W, Buchler MW. Late mortality in patients with severe acute pancreatitis. Br J Surg 2001; 88: 975-9.

32. Bradley EL III. A clinically based classification system for acute pancreatitis. Summary of the International Symposium on Acute Pancreatitis, Atlanta GA, September 11, through 13, 1992. Arch Surg 1993; 128: 586-90.

33. Ranson JH, Rifkind KM, Roses DF, Fink SD, Eng K, Spencer FC. Prognostic signs and the role of operative management in acute pancreatitis. Surg Gynecol Obstet 1974; 139: 69-81.

34. Ranson JH. The timing of biliary surgery in acute pancreatitis. Ann Surg 1979; 189: 654-63.

35. Larvin M. Assessment of clinical severity and prognosis. In: Beger HG, Warshaw AL, Buchler MW, Carr-Locke D, Neoptolemos JP, Russell C, Sarr MG (eds.). The pancreas. Oxford: Blackwell Science, 1998: 489-502.

36. Imrie CW, Benjamin IS, Ferguson JC, McKay AJ, Mackenzie I, O’Neill J, Blumgart LH. A single-centre double-blind trial of Trasylol therapy in primary acute pancreatitis. Br J Surg 1978; 65: 337–41.

37. Osborne DH, Imrie CW, Carter DC. Biliary surgery in the same admission for gallstone-associated acute pancreatitis. Br J Surg 1981; 68: 758-61.

38. Blamey SL, Imrie CW, O’Neill J, Gilmour WH, Carter DC. Prognostic factors in acute pancreatitis. Gut 1984; 25: 1340-6.

39. Agarwal N, Pitchumoni CS. Simplified prognostic criteria in acute pancreatitis. Pancreas 1986; 1: 69-73.

40. Rabeneck L, Feinstein AR, Horwitz RI, Wells CK. A new clinical prognostic staging system for acute pancreatitis. Am J Med 1993; 95: 61-70.

41. Larvin M, McMahon MJ. APACHE-II score for assessment and monitoring of acute pancreatitis. Lancet 1989; 2: 201-5.

42. Wilson C, Heath DI, Imrie CW. Prediction of outcome in acute pancreatitis: a comparative study of APACHE II, clinical assessment and multiple factor scoring system. Br J Surg 1990; 77: 1260-4.

43. Dominguez-Munoz JE, Carballo F, Garcia MJ, de Diego JM, Campos R, Yanguela J, de la Morena J. Evaluation of the clinical usefulness of APACHE II and SAPS systems in the initial prognostic classification of acute pancreatitis: a multicenter study. Pancreas 1993; 8: 682-6.

44. Le Gall JR, Lemeshow S, Saulnier F. A new Simplified Acute Physiology Score (SAPS II) based on a European/North American multicenter study. JAMA 1993; 270: 2957-63.

45. Chatzicostas C, Roussomoustakaki M, Vardas E, Romanos J, Kouroumalis EA. Balthazar computed tomography severity index is superior to Ranson criteria and APACHE II and III scoring systems in predicting acute pancreatitis outcome. J Clin Gastroenterol 2003; 36: 253-60.

46. Spitzer AL, Barcia AM, Schell MT, Barber A, Norman J, Grendell J, Harris HW. Applying Ockham’s razor to pancreatitis prognostication: a four-variable predictive model. Ann Surg 2006; 243: 380-8.

47. Pearce DB, Gunn SR, Ahmed A, Johnson CD. Machine learning can improve prediction of severity in acute pancreatitis using admission values of APACHE II score and C-reactive protein. Pancreatology 2006; 6: 123-31.

48. Werner J, Feuerbach S, Uhl W, Buchler MW. Management of acute pancreatitis: from surgery to interventional intensive care. Gut 2005; 54: 426-36.

49. Mofidi R, Duff MD, Wigmore SJ, Madhavan KK, Garden OJ, Parks RW. Association between early systemic inflammatory response, severity of multiorgan dysfunction and death in acute pancreatitis. Br J Surg 2006; 93: 738-44.

50. Martinez J, Johnson CD, Sanchez-Paya J, de Madaria E, Robles DG, Perez-Mateo M. Obesity is a definitive risk factor of severity and morality in acute pancreatitis: an updated metaanalysis. Pancreatology 2006; 6: 206-9.

51. Johnson DC, Toh SK, Campbell MJ. Combination of APACHE-II score and an obesity score (APACHE-O) for the prediction of severe acute pancreatitis. Pancreatology 2004; 4: 1-6.

52. Papachristou GI, Papachristou DJ, Avula H, Slivka A, Whitcomb DC. Obesity increases the severity of acute pancreatitis: performance of APACHE-O score and correlation with the inflammatory response. Pancreatology 2006; 6: 279-85.

53. Balthazar EJ, Robinson DL, Megibow AJ, Ranson JH. Acute pancreatitis: value of CT in establishing prognosis. Radiology 1990; 174: 331-6.

54. London NJ, Leese T, Lavelle JM, Miles K, West KP, Watkin DF, Fossard DP. Rapid-bolus contrast-enhanced dynamic computed tomography in acute pancreatitis: a prospective study. Br J Surg 1991; 78: 1452-6.

55. Simchuk EJ, Traverso LW, Nukui YM, Kozarek RA. Computed tomography severity index is a predictor of outcomes for severe pancreatitis. Am J Surg 2000; 179: 352-5.

56. Perez A, Whang EE, Brooks DC, Moore FD Jr, Hughes MD, Sica GT, Zinner MJ, Ashley SW, Banks PA. Is severity of necrotizing pancreatitis increased in extended necrosis and infected necrosis? Pancreas 2002; 25: 229-33.

57. Garg PK, Madan K, Pande GK, Khanna S, Sathyanarayan G, Bohidar NP, Tandon RK. Association of extent and infection of pancreatic necrosis with organ failure and death in acute necrotizing pancreatitis. Clin Gastroenterol Hepatol 2005; 3: 159-66.

58. Karimgani I, Porter KA, Langevin RE, Banks PA. Prognostic factors in sterile pancreatic necrosis. Gastroenterology 1992; 103: 1636-40.

59. Tenner S, Sica G, Hughes M, Noordhoek E, Feng S, Zinner M, Banks PA. Relationship of necrosis to organ failure in severe acute pancreatitis. Gastroenterology 1997;113: 899-903.

60. Hirota M, Kimura Y, Ishiko T, Beppu T, Yamashita Y, Ogawa M. Visualization of the heterogeneous internal structure of socalled “pancreatic necrosis” by magnetic resonance imaging in acute necrotizing pancreatitis. Pancreas 2002; 25: 63-7.

61. Matos C, Bali MA, Delhaye M, Deviere J. Magnetic resonance imaging in the detection of pancreatitis and pancreatic neoplasms. Best Pract Clin Gastroenterol 2006; 20: 157-78.

62. Robert JH, Frossard JL, Mermillod B, Soravia C, Mensi N, Roth M, Rohner A, Hadengue A, Morel P. Early prediction of acute pancreatitis: prospective study comparing computed tomography scans, Ranson, Glasgow, Acute Physiology and Chronic Health Evaluation II scores, and various serum markers. World J Surg 2002; 26: 612-19.

63. Gurleyik G, Emir S, Kilicoglu G, Arman A, Saglam A. Computed tomography severity index, APACHE II score, and serum CRP concentration for predicting the severity of acute pancreatitis. JOP 2005; 6: 562-7.

64. De Sanctis JT, Lee MJ, Gazelle GS, Boland GW, Halpern EF, Saini S, Mueller PR. Prognostic indicators in acute pancreatitis: CT vs. APACHE II. Clin Radiol 1997; 52: 842-8.

65. Isenmann R, Rau B, Beger HG. Early severe acute pancreatitis: characteristics of a new subgroup. Pancreas 2001; 22: 274-8.

66. Buter A, Imrie CW, Carter CR, Evans S, McKay CJ. Dynamic nature of early organ dysfunction determines outcome in acute pancreatitis. Br J Surg 2002; 89: 298-302.

67. Johnson CD, Abu-Hilal M. Persistent organ failure during the first week as a marker of fatal outcome in acute pancreatitis. Gut 2004; 53: 1340-4.

68. Poves PI, Fabregat PJ, Garcia BFJ, Jorba MR, Figueras FJ, Jaurrieta ME. Early onset of organ failure is the best predictor of morality in acute pancreatitis. Rev Esp Enferm Dig 2004; 96: 705-13.

69. Marshall JC, Cook DJ, Christou NV, Bernard GR, Sprung CL, Sibbald WJ. Multiple organ dysfunction score: a reliable descriptor of a complex clinical outcome. Crit Care Med 1995; 23: 1638-52.

70. Vincent JL, Moreno R, Takala J, Willatts S, De Mendonca A, Bruining H, Reinhart CK, Suter PM, Thijs LG. The SOFA (Sepsisrelated Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis Related Problems of the European Society of Intensive Care Medicine. Intensive Care Med 1996; 22: 707-10.

71. Brown A, Orav J, Banks PA. Hemoconcentration is an early marker for organ failure and necrotizing pancreatitis. Pancreas 2000; 20: 367-72.

72. Lankisch PG, Mahlke R, Blum T, Bruns A, Bruns D, Maisonneuve P, Lowenfels AB. Hemoconcentration: an early marker of severe and/or necrotizing pancreatitis? A critical appraisal. Am J Gastroenterol 2001; 96: 2081-5.

73. Baillargeon JD, Orav J, Ramagopal V, Tenner SM, Banks PA. Hemoconcentration as an early risk factor for necrotizing pancreatitis. Am J Gastroenterol 1998; 93: 2130-4.

74. Remes-Troche JM, Duarte-Rojo A, Morales G, Robles-Diaz G. Hemoconcentration is a poor predictor of severity in acute pancreatitis. World J Gastroenterol 2005; 11: 7018-23.

75. Blum T, Maisonneuve P, Lowenfels AB, Lankisch PG. Fatal outcome in acute pancreatitis: its occurrence and early prediction. Pancreatology 2001; 1: 273-41.

76. Rettally C, Skarda S, Garza MA, Schenker S. The usefulness of laboratory tests in the early assessment of severity of acute pancreatitis. Crit Rev Clin Lab Sci 2003; 40: 117-49.

77. Kingsnorth A, O’Reilly D. Acute pancreatitis. BMJ 2006; 332: 1072-6.

78. Whitcomb DC. Clinical practice. Acute pancreatitis. N Engl J Med 2006; 354: 2142-50.

79. Chak A, Hawes RH, Cooper GS, Hoffman B, Catalano MF, Wong RC, Herbener TE, Sivak MV Jr. Prospective assessment of the utility of EUS in the evaluation of gallstone pancreatitis. Gastrointest Endosc 1999; 49: 599-604.

80. Liu CL, Lo CM, Chan JK, Poon RT, Lam CM, Fan ST, Wong J. Detection of choledocholithiasis by EUS in acute pancreatitis: a prospective evaluation in 100 consecutive patients. Gastrointest Endosc 2001; 54: 325-30.

81. Ammori BJ, Boreham B, Lewis P, Roberts SA. The biochemical detection of biliary etiology of acute pancreatitis on admission: a revisit in the modern era of biliary imaging. Pancreas 2003; 26: e32-e35.

82. Levy P, Boruchowicz A, Hastier P, Pariente A, Thevenot T, Frossard JL, Buscail L, Mauvais F, Duchmann JC, Courrier A, Bulois P, Gineston JL, Barthet M, Licht H, O’Toole D, Ruszniewski P. Diagnostic criteria in predicting a biliary origin of acute pancreatitis in the era of endoscopic ultrasound: multicentre prospective evaluation of 213 patients. Pancreatology 2005; 5: 450-6.

83. Liu CL, Fan ST, Lo CM, Tso WK, Wong Y, Poon RT, Lam CM, Wong BC, Wong J. Clinico-biochemical prediction of biliary cause of acute pancreatitis in the era of endoscopic ultrasonography. Aliment Pharmacol Ther 2005; 22: 423-31.

84. Steinberg WM, Chari ST, Forsmark CE, Sherman S, Reber HA, Bradley EL III, DiMagno E. Controversies in clinical pancreatology: management of acute idiopathic recurrent pancreatitis. Pancreas 2003; 27: 103-17.

85. Steinberg WM. Controversies in clinical pancreatology: should the sphincter of Oddi be measured in patients with idiopathic recurrent acute pancreatitis, and should sphincterotomy be performed if the pressure is high? Pancreas 2003; 27: 118-21.

86. Petersen BT. Sphincter of Oddi dysfunction, part 2: evidence based review of the presentations, with “objective” pancreatic findings (types I and II) and of presumptive type III. Gastrointest Endosc 2004; 59: 670-87.

87. Runzi M, Layer P. Drug-associated pancreatitis: facts and fiction. Pancreas 1996; 13: 100-9.

88. Lancashire RJ, Cheng K, Langman MJ. Discrepancies between population-based data and adverse reaction reports in assessing drugs as causes of acute pancreatitis. Aliment Pharmacol Ther 2003; 17: 887-93.

89. Lara LP, Chari ST. Autoimmune pancreatitis. Curr Gastroenterol Rep 2005; 7: 101-6.

90. Chari ST, Smyrk TC, Levy MJ, Topazian MD, Takahashi N, Zhang L, Clain JE, Pearson RK, Petersen BT, Vege SS, Farnell MB. Diagnosis of autoimmune pancreatitis: the Mayo Clinic experience. Clin Gastroenterol Hepatol 2006; 4: 1010-16.

91. Whitcomb DC, Gorry MC, Preston RA, Furey W, Sossenheimer MJ, Ulrich CD, Martin SP, Gates LK Jr, Amann ST, Toskes PP, Liddle R, McGrath K, Uomo G, Post JC, Ehrlich GD. Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene. Nat Genet 1996; 14: 141-5.

92. Vitone LJ, Greenhalf W, Howes NR, Raraty MG, Neoptolemos JP. Trypsinogen mutations in pancreatic disorders. Endocrinol Metab Clin North Am 2006; 35: 271-87.

93. Cohn JA, Noone PG, Jowell PS. Idiopathic pancreatitis related to CFTR: complex inheritance and identification of a modifier gene. J Invest Med 2002; 50: 247S-255S.

94. Cohn JA, Bornstein JD, Jowell PS. Cystic fibrosis mutations and genetic predisposition to idiopathic chronic pancreatitis. Med Clin North Am 2000; 84: 621-31.

95. Gelrud A, Sheth S, Banerjee S, Weed D, Shea J, Chuttani R, et al. Analysis of cystic fibrosis gene product (CFTR) function in patients with pancreas divisum and recurrent acute pancreatitis. Am J Gastroenterol 2004; 99: 1557-62.

96. Schneider A. Serine protease inhibitor kazal type 1 mutations and pancreatitis. Clin Lab Med 2005; 25: 61-78.

97. Tukiainen E, Kylanpaa ML, Kemppainen E, Nevanlinna H, Paju A, Repo H, Stenman UH, Puolakkainen P. Pancreatic secretory trypsin inhibitor (SPINK1) gene mutations in patients with acute pancreatitis. Pancreas 2005; 30: 239-42.

98. NIH state-of-the-science statement on endoscopic retrograde cholangiopancreatography (ERCP) for diagnosis and therapy. NIH Consens State Sci Statements 2002; 19: 1-26.

99. Evans WB, Draganov P. Is empiric cholecystectomy a reasonable treatment option for idiopathic pancreatitis? Nat Clin Pract Gastroenterol Hepatol 2006; 3: 356-7.

100. Draganov P, Forsmark CE. “Idiopathic” pancreatitis. Gastroenterology 2005; 128: 756-63.

101. Wilcox MC, Varadarajulu S, Eloubeidi M. Role of endoscopic evaluation in idiopathic pancreatitis: a systematic review. Gastrointest Endosc 2006; 63: 1037-45.

102. Ballinger AB, Barnes E, Alstead EM, Fairclough PD. Is intervention necessary after a first episode of acute pancreatitis? Gut 1996; 38: 293-5.

103. Lankisch PG, Breuer N, Bruns A, Weber-Dany B, Maisonneuve P, Lowefels P. The natural course of acute idiopathic pancreatitis (abstr). Pancreas 2006; 33: 476.

104. Knol JA, Inman MG, Strodel WE, Eckhauser FE. Pancreatic response to crystalloid resuscitation in experimental pancreatitis. J Surg Res 1987; 43: 387-92.

105. Niederau C, Crass RA, Silver G, Ferrell LD, Grendell JH. Therapeutic regimens in acute experimental hemorrhagic pancreatitis. Effects of hydration, oxygenation, peritoneal lavage, and a potent protease inhibitor. Gastroenterology 1988; 95: 1648-57.

106. Brown A, Baillargeon JD, Hughes MD, Banks PA. Can fluid resuscitation prevent pancreatic necrosis in severe acute pancreatitis? Pancreatology 2002; 2: 104-7.

107. Beger HG, Bittner R, Buchler M, Hess W, Schmitz JE. Hemodynamic data pattern in patients with acute pancreatitis. Gastroenterology 1986; 90: 74-9.

108. Forsmark CE, Grendell JH. Complications of pancreatitis. In: Sleisenger MH, Fordtran JS, Cello JP, Grendell JH (eds.). Seminars in gastrointestinal disease: diagnosis and treatment of acute and chronic pancreatitis. Philadelphia, PA: 1991: 165-76.

109. Turina M, Fry DE, Polk HC Jr. Acute hyperglycemia and the innate immune system: clinical, cellular, and molecular aspects. Crit Care Med 2005; 33: 1624-33.

110. Yadav D, Pitchumoni CS. Issues in hyperlipidemic pancreatitis. J Clin Gastroenterol 2003; 36: 54-62.

111. Thompson DR. Narcotic analgesic effects on the sphincter of Oddi: a review of the data and therapeutic implications in treating pancreatitis. Am J Gastroenterol 2001; 96: 1266-72.

112. Kaushik N, Pietraszewski M, Holst JJ, O’Keefe SJ. Enteral feeding without pancreatic stimulation. Pancreas 2005; 31: 353-9.

113. Vu MK, van der Veek PP, Frolich M, Souverijn JH, Biemond I, Lamers CB, Masclee AA. Does jejunal feeding activate exocrine pancreatic secretion? Eur J Clin Invest 1999; 29: 1053-9.

114. Marik PE, Zaloga GP. Meta-analysis of parenteral nutrition versus enteral nutrition in patients with acute pancreatitis. BMJ 2004; 328: 1407.

115. O’Keefe SJ, Lee RB, Anderson FP, Gennings C, Abou-Assi S, Clore J, Heuman D, Chey W. Physiological effects of enteral and parenteral feeding on pancreaticobillary secretion in humans. Am J Physiol Gastrointest Liver Physiol 2003; 284: G27-G36.

116. O’Keefe SJ, Lee RM, Li J, Stevens S, Abou-Assi S, Zhou W. Trypsin secretion and turnover in patients with acute pancreatitis. Am J Physiol Gastrointest Liver Physiol 2005; 289: G181-G187.

117. Eatock FC, Chong P, Menezes N, Murray L, McKay CJ, Carter CR, Imrie CW. A randomized study of early nasogastric versus nasojejunal feeding in severe acute pancreatitis. Am J Gastroenterol 2005; 100: 432-9.

118. Kumar A, Singh N, Prakash S, Saraya A, Joshi YK. Early enteral nutrition in severe acute pancreatitis: a prospective randomized controlled trial comparing nasojejunal and nasogastric routes. J Clin Gastroenterol 2006; 40: 431-4.

119. Eckerwall GE, Axelsson JB, Andersson RG. Early nasogastric feeding in predicted severe acute pancreatitis: a clinical, randomized study. Ann Surg 2006; 244: 959-67.

120. Andriulli A, Leandro G, Clemente R, Festa V, Caruso N, Annese V, Lezzi G, Lichino E, Bruno F, Perri F. Meta-analysis of somatostatin, octreotide and gabexate mesilate in the therapy of acute pancreatitis. Aliment Pharmacol Ther 1998; 12: 237-45.

121. Uhl W, Buchler MW, Malfertheiner P, Beger HG, Adler G, Gaus W. A randomised, double blind, multicentre trial of octreotide in moderate to severe acute pancreatitis. Gut 1999; 45: 97-104.

122. Messori A, Rampazzo R, Scroccaro G, Olivato R, Bassi C, Falconi M, Pederzoli P, Martini N. Effectiveness of gabexate mesilate in acute pancreatitis. A metaanalysis. Dig Dis Sci 1995; 40: 734-8.

123. Larvin M. A double-blind randomized multi-centre trial of lexipafant in acute pancreatitis (abstr). Pancreas 2001; 23: 448.

124. Forsmark CE. The clinical problem of biliary acute necrotizing pancreatitis: epidemiology, pathophysiology, and diagnosis of biliary necrotizing pancreatitis. J Gastrointest Surg 2001; 5: 235-9.

125. Neoptolemos JP, Carr-Locke DL, London NJ, Bailey IA, James D, Fossard DP. Controlled trial of urgent endoscopic retrograde cholangiopancreatography and endoscopic sphincterotomy versus conservative treatment for acute pancreatitis due to gallstones. Lancet 1988; 2: 979-83.

126. Fan ST, Lai EC, Mok FP, Lo CM, Zheng SS, Wong J. Early treatment of acute biliary pancreatitis by endoscopic papillotomy. N Engl J Med 1993; 328: 228-32.

127. Folsch UR, Nitsche R, Ludtke R, Hilgers RA, Creutzfeldt W. Early ERCP and papillotomy compared with conservative treatment for acute biliary pancreatitis. The German Study Group on Acute Biliary Pancreatitis. N Engl J Med 1997; 336: 237-42.

128. Oria A, Cimmino D, Ocampo C, Silva W, Kohan G, Zandalazini H, Szelagowski C, Chiappetta L. Early endoscopic intervention versus early conservative management in patients with acute gallstone pancreatitis and biliopancreatic obstruction. A randomized clinical trial. Ann Surg 2007; 245: 10-17.

129. Sharma VK, Howden CW. Metaanalysis of randomized controlled trials of endoscopic retrograde cholangiography and endoscopic sphincterotomy for the treatment of acute biliary pancreatitis. Am J Gastroenterol 1999; 94: 3211-14.

130. Heinrich S, Schafer M, Rousson V, Clavien PA. Evidence-based treatment of acute pancreatitis: a look at established paradigms. Ann Surg 2006; 243: 154-68.

131. Aybu K, Imada R, Slavin J. Endoscopic retrograde cholangiopancreatography in gallstone-associated acute pancreatitis. Cochrane Database Syst Rev 2004; CD003630.

132. Davidson BR, Neoptolemos JP, Carr-Locke DL. Endoscopic sphincterotomy for common bile duct calculi in patients with gall bladder in situ considered unfit for surgery. Gut 1988; 29: 114-20.

133. Shemesh E, Czerniak A, Schneabaum S, Nass S. Early endoscopic sphincterotomy in the management of acute gallstone pancreatitis in elderly patients. J Am Geriatr Soc 1990; 38: 893-6.

134. Hill J, Martin DF, Tweedle DE. Risks of leaving the gallbladder in situ after endoscopic sphincterotomy for bile duct stones. Br J Surg 1991; 78: 554-7.

135. Siegel JH, Veerappan A, Cohen SA, Kasmin FE. Endoscopic sphincterotomy for biliary pancreatitis: an alternative to cholecystectomy in high-risk patients. Gastrointest Endosc 1994; 40: 573-5.

136. Wellbourn CR, Beckly DE, Eyre-Brook IA. Endoscopic sphincterotomy without cholecystectomy for gall stone pancreatitis. Gut 1995; 37: 119-20.

137. Uomo G, Manes G, Laccetti M, Cavallera A, Rabitti PG. Endoscopic sphincterotomy and recurrence of acute pancreatitis in gallstone patients considered unfit for surgery. Pancreas 1997; 14: 28-31.

138. Gislason H, Vetrhus M, Horn A, Hoem D, Sondenaa K, Soreide O, Viste A, Andren-Sandberg A. Endoscopic sphincterotomy in acute gallstone pancreatitis: a prospective study of the late outcome. Eur J Surg 2001; 167: 204-8.

139. Kaw M, Al-Antably Y, Kaw P. Management of gallstone pancreatitis: cholecystectomy or ERCP and endoscopic sphincterotomy. Gastrointest Endosc 2002; 56: 61-5.

140. Erickson RA. Carlson B. The role of endoscopic retrograde cholangiopancreatography in patients with laparoscopic cholecystectomies. Gastroenterology 1995; 109: 252-63.

141. Chang L, Lo S, Stabile BE, Lewis RJ, Toosie K, de Virgilio C. Preoperative versus postoperative endoscopic retrograde cholangiopancreatography in mild to moderate gallstone pancreatitis: a prospective randomized trial. Ann Surg 2000; 231: 82-7.

142. Urbach DR, Khajanchee YS, Jobe BA, Standage BA, Hansen PD, Swanstrom LL. Cost-effective management of common bile duct stones: a decision analysis of the use of endoscopic retrograde cholangiopancreatography (ERCP) intraoperative cholangiography, and laparoscopic bile duct exploration. Surg Endosc 2001; 15: 4-13.

143. Liu CL, Fan ST, Lo CM, Tso WK, Wong Y, Poon RT, Lam CM, Wong BC, Wong J. Comparison of early endoscopic ultrasonography and endoscopic retrograde cholangiopancreatography in the management of acute biliary pancreatitis: a prospective randomized study. Clin Gastroenterol Hepatol 2005; 3: 1238-44.

144. Pederzoli P, Bassi C, Vesentini S, Campbedelli A. A randomized multicenter clinical trial of antibiotic prophylaxis of septic complications in acute necrotizing pancreatitis with imipenem. Surg Gynecol Obstet 1993; 176: 480-3.

145. Luiten EJ, Hop WC, Lange JF, Bruining HA. Controlled clinical trial of selective decontamination for the treatment of severe acute pancreatitis. Ann Surg 1995; 222: 57-65.

146. Sainio V, Kemppainen E, Puolakkainen P, Taavitsainen M, Kivisaari L, Valtonen V, Haapiainen R, Schroder T, Kivilaakso E. Early antibiotic treatment in acute necrotizing pancreatitis. Lancet 1995; 346: 663-7.

147. Delcenserie R, Yzet T, Ducrois JP. Prophylactic antibiotics in treatment of severe acute alcoholic pancreatitis. Pancreas 1996; 13: 198-201.

148. Schwarz M, Isenmann R, Meyer H, Berger HG. Antibiotic use in necrotizing pancreatitis. Results of a controlled study. Dtsch Med Wochenschr 1997; 122: 356-61.

149. Nordback I, Sand J, Saaristo R, Paajanen J. Early treatment with antibiotics reduces the need for surgery in acute necrotizing pancreatitis a single center randomized study. J Gastrointest Surg 2001; 5: 113-18; discussion 118-20.

150. Isenmann R, Runzi M, Kron M, Kahl S, Kraus D, Jung N, Maier L, Malfertheiner P, Goebell H, Beger HG; German Antibiotics in Severe Acute Pancreatitis Study Group. Prophylactic antibiotic treatment in patients with predicted severe acute pancreatitis: a placebo-controlled, double-blind trial. Gastroenterology 2004; 126: 997-1004.

151. Dellinger RP, Tellado JM, Soto NE, Ashley SW, Barie PS, Dugernier T, Imrie CW, Johnson CD, Knaebel HP, Laterre PF, MaraviPoma E, Kissler JJO, Sanchez-Garcia M, Utzolino S. Early antibiotic treatment for severe acute necrotizing pancreatitis: Randomized, double-blind, placebo-controlled study. Ann Surg 2007; 245(5): 674-83.

152. Bassi C, Larvin M, Villatoro E. Antibiotic therapy for prophylaxis against infection of pancreatic necrosis in acute pancreatitis. Cochrane Database Syst Rev 2003; CD002941.

153. Moyshenyat I, Mandell E, Tenner S. Antibiotic prophylaxis of pancreatic infection in patients with necrotizing pancreatitis: rationale, evidence, and recommendations. Curr Gastroentrol Rep 2006; 8: 121-6.

154. Besselink MGH, de Vries AC, van de Kraats CIB, Buskens E, Van Erpecum KJ, Gooszen HG. Antibiotic prophylaxis in necrotizing pancreatitis: relationship of methodological quality of randomized trials to outcome (abstr). Pancreas 2006; 33: 446.

155. Working Party of the British Society of Gastroenterology; Association of Surgeons of Great Britain and Ireland: Pancreatic Society of Great Britain and Ireland: Association of Upper GI Surgeons of Great Britain and Ireland. UK guidelines for the management of acute pancreatitis. Gut 2005; 54(Suppl. 3): iii1-iii9.

156. Bassi C, Falconi M, Talamini G, Uomo G, Papaccio G, Dervenis C, Salvia R, Minelli EB, Pederzoli P. Controlled clinical trial of perfloxacin versus imipenem in severe acute pancreatitis. Gastroenterology 1998; 115: 1513-17.

157. Gerzof SG, Banks PA, Robbins AH, Johnson WC, Spechler SJ, Wetzner SM, Snider JM, Langevin RE, Jay ME. Early diagnosis of pancreatic infection by computed tomography-guided aspiration. Gastroenterology 1987; 93: 1315-20.

158. Banks PA, Gerzof SG, Langevin RE, Silverman SG, Sica GT, Hughes MD. CT-guided aspiration of suspected pancreatic infection: bacteriology and clinical outcome. Int J Pancreatol 1995; 18: 265-70.

159. Rau B, Pralle U, Mayer JM, Berger HG. Role of ultrasonographically guided fine-needle aspiration cytology in the diagnosis of infected pancreatic necrosis. Br J Surg 1998; 85: 179-84.

160. Connor S, Ghaneh P, Raraty M, Sutton R, Rosso E, Garvey CJ, Hughes ML, Evans JC, Rowlands P, Neoptolemos JP. Minimally invasive retroperitoneal pancreatic necrosectomy. Dig Surg 2003; 20: 270-7.

161. Parekh D. Laparoscopic-assisted pancreatic necrosectomy: a new surgical option for treatment of severe necrotizing pancreatitis. Arch Surg 2006; 141: 895-902, discussion 902-3.

162. Chang YC, Tsai HM, Lin XZ, Chang CH, Chuang JP. No debridement is necessary for symptomatic or infected acute necrotizing pancreatitis: delayed, min-retroperitoneal drainage for acute necrotizing pancreatitis without debridement and irrigation. Dig Dis Sci 2006; 51: 1388-95.

163. Freeny PC, Hauptmann E, Althaus SJ, Traverso LW, Sinanan M. Percutaneous CT-guided catheter drainage of infected acute necrotizing pancreatitis: techniques and results. Am J Roentgenol 1998; 170: 969-75.

164. Szentkereszty Z, Kerekes L, Hallay J, Czako D, Sapy Y. CTguided percutaneous peripancreatic drainage: a possible therapy in acute necrotizing pancreatitis. Hepatogastroenterology 2002; 49: 1696-8.

165. Endilcher E, Volk M, Feruerbach S, Scholmerich J, Schaffler A, Messmann H. Long-term follow-up of patients with necrotizing pancreatitis treated by percutaneous necrosectomy. Hepatogastroenterology 2003; 50: 2225-8.

166. Echenique AM, Sleeman D, Yrizarry J, Scagnelli T, Guerra JJ Jr, Casillas VJ, Huson H, Russell E. Percutaneous catheter-directed debridement of infected pancreatic necrosis: results in 20 patients. J Vasc Interv Radiol 1998; 9: 565-71.

167. Baron TH, Thaggard WG, Morgan DE, Stanley RJ. Endoscopic therapy for organized pancreatic necrosis. Gastroenterology 1996; 111: 755-64.

168. Baron TH, Harewood GC, Morgan DE, Yates MR. Outcome differences after endoscopic drainage of pancreatic necrosis acute pancreatic pseudocysts, and chronic pancreatic pseudocysts. Gastrointest Endosc 2002; 56: 7-17.

169. Baron TH. Endoscopic drainage of pancreatic fluid collections and pancreatic necrosis. Gastrointest Endosc Clin North Am 2003; 13: 743-64.

170. Seewald S, Groth S, Omar S, Imazu H, Seitz U, de Weerth A, Soetikno R, Zhong Y, Sriram PV, Ponnudurai R, Sikka S, Thonke F, Soehendra N. Aggressive endoscopic therapy for pancreatic necrosis and pancreatic abscess: a new safe and effective treatment algorithm (videos). Gastrointest Endosc 2005; 62: 92-100.

171. Vege SS, Baron TH. Management of pancreatic necrosis in severe acute pancreatitis. Clin Gastroenterol Hepatol 2005; 3: 192-6.

172. Dubner H, Steinberg W, Hill M, Bassi C, Chardavoyne R, Bank S. Infected pancreatic necrosis and peripancreatic fluid collections: serendipitous response to antibiotics and medical therapy in three patients. Pancreas 1996; 12: 298-302.

173. Ramesh H, Prakash K, Lekha V, Jacob G, Venugopal A. Are some cases of infected pancreatic necrosis treatable without intervention? Dig Surg 2003; 20: 296-9.

174. Baillie J. Pancreatic pseudocysts (part I). Gastrointest Endosc 2004; 59: 873-9.

175. Baillie J. Pancreatic pseudocysts (part II). Gastrointest Endosc 2004; 60: 105-13.

176. Freeman ML, DiSario JA, Nelson DB, Fennerty MB, Lee JG, Bjorkman DJ, et al. Risk factors for post-ERCP pancreatitis: a prospective, multicenter study. Gastrointest Endosc 2001; 54: 425-34.

177. Cheng C-L, Sherman S, Watkins JL, Barnett J, Freeman M, Geenen J, Ryan M, Parker H, Frakes JT, Fogel EL, Silverman WB, Dua KS, Aliperti G, Yakshe P, Uzer M, Jones W, Goff J, LazzellPannell L, Rashdan A, Temkit M, Lehman GA. Risk factors for post-ERCP pancreatitis: a prospective multicenter study. Am J Gastroenterol 2006; 101: 139-47.

178. Freeman ML, Nelson DB, Sherman S, Haber GB, Herman ME, Dorsher PJ, Moore JP, Fennerty MB, Ryan ME, Shaw MJ, Lande JD, Pheley AM. Complications of endoscopic biliary sphincterotomy. N Engl J Med 1996; 335: 909-18.

179. Vandervoort J, Soetikno RM, Tham TC, Wong RC, Ferrari AP Jr, Montes H, et al. Risk factors for complications after performance of ERCP. Gastrointest Endosc 2002; 56: 652-6.

180. Friedland S, Soetikno RM, Vandervoort J, Montes H, Tham T, Carr-Locke DL. Bedside scoring system to predict the risk of developing pancreatitis following ERCP. Endoscopy 2002; 34: 483-8.

181. Masci E, Toti G, Mariani A, Curioni S, Lomazzi A, Dinelli M, et al. Complications of diagnostic and therapeutic ERCP: a prospective multicenter study. Am J Gastroenterol 2001; 96: 417-23.

182. Masci E, Mariani A, Curioni S, Testoni PA. Risk factors for pancreatitis following endoscopic retrograde cholangiopancreatography: a meta analysis. Endoscopy 2003; 35: 830-4.

183. Cotton PB. ERCP is not dangerous for people who need it least. Gastrointest Endosc 2001; 54: 535-6.

184. ERCP core curriculum. Gastrointest Endosc 2006; 63: 361-76.

185. Pande H, Thuluvath P. Pharmacologic prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis. Drugs 2003; 63: 1799-812.

186. Freeman ML, Guda NM. Prevention of post-ERCP pancreatitis: a comprehensive review. Gastrointest Endosc 2004; 59: 845-64.

187. Andruilli A, Leandro G, Niro G, Mangia A, Festa V, Gambassi G, Villani MR, Facciorusso D, Conoscitore P, Spirito F, De Maio G. Pharmacologic treatment can prevent pancreatic injury after ERCP: a meta-analysis. Gastrointest Endosc 2000; 51: 1-7.

188. Andriulli A, Caruso N, Quitadamo M, Forlano R, Leandro G, Spirito F, De Maio G. Antisecretory vs. antiproteases drugs in the prevention of post-ERCP pancreatitis: the evidence-based medicine derived from a meta-analysis study. JOP 2003; 4: 41-8.

189. Murray B, Carter R, Imrie C, Evans S, O’Suilleabhain C. Diclofenac reduces the incidence of acute pancreatitis after endoscopic retrograde cholangiography. Gastroenterology 2003; 124: 1786-91.

190. Singh P, Das A, Isenberg G, Wong RC, Sivak MV Jr, Agrawal D, Chak A. Does prophylactic pancreatic stent placement reduce the risk of post-ERCP acute pancreatitis? A meta-analysis of controlled trials. Gastrointest Endosc 2004; 60: 544-50.

191. Freeman ML, Overby C, Qi D. Pancreatic stent insertion: consequences of failure and results of a modified technique to maximize success. Gastrointest Endosc 2004; 59: 8-14.