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Asociación Mexicana de Gastroenterología

2007, Número 2

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Rev Gastroenterol Mex 2007; 72 (2)


El papel de la investigación translacional en la enfermedad inflamatoria intestinal

Abreu MT, Sparrow MP

Idioma: Español
Referencias bibliográficas: 48
Paginas: 146-153
Archivo PDF: 123.30 Kb.


RESUMEN

Las enfermedades inflamatorias intestinales idiopáticas, clasificadas de manera general como enfermedad de Crohn o colitis ulcerativa, son causadas por una respuesta inmune mal regulada de la mucosa a un antígeno luminal, posiblemente una bacteria, en un huésped genéticamente predispuesto. Una rápida expansión del conocimiento en años recientes ha aumentado enormemente nuestro entendimiento de la patofisiología de estos trastornos. Por ejemplo, el descubrimiento relativamente reciente del gen NOD2, una proteína involucrada en la percepción bacteriana, ha proporcionado mayor evidencia de la compleja interacción entre huéspedes y microbios en la enfermedad de Crohn. También han ocurrido avances recientes significativos con el descubrimiento del papel de los receptores tipo Toll y de las células dendríticas en el desarrollo de la inflamación intestinal, y el papel de citoquinas proinflamatorias en el desarrollo y la potenciación de la inflamación intestinal. Este artículo presenta una actualización de estos desarrollos clave y enfatiza los aspectos translacionales de la investigación básica que están directamente relacionados con la atención del paciente.


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