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Anales de la Sociedad Mexicana de Oftalmología y Archivos de la Asociación Para Evitar la Ceguera en México

2004, Número 2

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Rev Mex Oftalmol 2004; 78 (2)


Nuevos e intrigantes conceptos en la oncogénesis del retinoblastoma. Análisis y revisión del tema

González-Almaraz G, Pineda-Cárdenas MAA, Garza-Ruíz E

Idioma: Español
Referencias bibliográficas: 105
Paginas: 57-70
Archivo PDF: 655.45 Kb.


RESUMEN

El retinoblastoma es una neoplasia maligna de la infancia, se origina en la retina y tiene un patrón hereditario bien definido autosómico dominante de penetración variable, puede asociarse a monosomías, translocaciones parciales, isocromosomas y mosaicismo. Las formas esporádicas pueden representar la forma inicial del rasgo familiar. En pacientes con formas hereditarias de la neoplasia y que sobreviven, se comprueba la posibilidad de desarrollar pinealomas y segundos tumores sin relación con la radiación, así como la acción de los sistemas de c-proto-oncogenes, anti-oncogenes y oncogenes relacionados con alteraciones en las proteínas supresoras que modifican los ciclos de proliferación celular.
El consejo genético esta en relación con la acción de los genes y juega un papel muy importante en el futuro de esta neoplasia.


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