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Instituto Nacional de Salud Pública

2004, Número 6

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salud publica mex 2004; 46 (6)


Helicobacter pylori: enfoque sobre los factores de virulencia CagA y VacA.

Castillo-Rojas G, Mazarí-Hiriart M, López-Vidal Y

Idioma: Ingles.
Referencias bibliográficas: 90
Paginas: 538-548
Archivo PDF: 136.74 Kb.


RESUMEN

Después de colonizar la mucosa gástrica humana, Helicobacter pylori puede permanecer por años e incluso décadas en el humano, y se asocia a varias patologías gástricas. En México, la seroprevalencia estimada es de 20% en niños de un año de edad, con una tasa de incremento en seropositividad de 5% anual durante los primeros 10 años de vida hasta alcanzar 80% en adultos jóvenes entre los 18 y 20 años de edad. Los factores bacterianos de virulencia propuestos para H. pylori son ureasa, flagelos, proteínas de choque térmico, lipopolisacárido, adhesinas, citotoxina vacuolizante, isla de patogenicidad y la proteína asociada a la citoxina; este último factor es el más estudiado hasta la fecha.


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