Vega FL

Idioma: Español
Referencias bibliográficas: 21
Paginas: 230-232
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FRAGMENTO

Hace justamente veinte años Oski y Honig comunicaron que los cocientes de desarrollo mental de lactantes anémicos aumentaban significativamente después de ser tratados con hierro dextran, por vía intramuscular. El hallazgo era congruente con algunas observaciones clínicas en pacientes anémicos y con los resultados de estudios experimentales en ratas deficientes en hierro; los informes describían en los niños, cambios conductuales caracterizados por letargia e irritabilidad y mencionaban que las ratas mostraban menor actividad espontánea y respondían con lentitud al ser estimuladas.

REFERENCIAS (EN ESTE ARTÍCULO)

1. Oski FA, Honig AS. The effects of therapy on the developmental scores of iron-deficient infants. Pediatrics 1978; 92: 21-5.

2. Mauer AM. Pediatric hematology. New York: McGraw Hill Book Company, 1969: 195-220.

3. Glover J, Jacobs A. Activity pattern of iron-deficient rats. Brit Med J 1972; 2: 627-8.

4. Symes AL, Missala K, Sourkes TL. Iron and riboflavin-dependent metabolism of a monoamine in the rat in vivo. Science 1971; 174: 153-6.

5. Voorhess ML, Stuart MJ, Stockman JA, Oski FA. Iron deficiency anemia and increased urinary norepinephrine excretion. J Pediatr 1975; 86: 542-7.

6. Dillman E, Mackler B, Johnson D et al. Effect of iron deficiency on catecholamine metabolism and body temperature regulation. En: Pollitt E, Leibel RL, Ed. Iron deficiency: Brain Biochemistry and behavior. New York; Raven Press 1982: 57-77.

7. Oski FA, Honig AS, Helu B, Howanitz P. Effect of iron therapy on behavior performance in nonanemic, iron deficient infants. Pediatrics 1983; 71: 877-80.

8. Lozoff B, Brittenham GM, Viteri FE, Wolf AW, Urrutia JJ. The effects of short-term oral iron therapy on developmental deficits in iron-deficient anemic infants. J Pediatr 1982; 100: 351-7.

9. Walter T, Kovalskys J, Stekel A. Effect of mild iron deficiency on infant mental development scores. J Pediatr 1983; 102: 519-22.

10. Walter T, de Andracal I, Chadud P, Perales CG. Iron deficiency anemia: adverse effects on infant psychomotor development. Pediatrics 1989; 84: 7-17.

11. Lozoff B, Brittenham GM, Wolf AW et al. Iron deficiency anemia and iron therapy: effects on infant developmental test performance. Pediatrics 1987; 79: 981-95.

12. Aukett MA, Parks YA, Scott PH, Wharton BA. Treatment with iron increase weight gain and psychomotor development. Arch Dis Child 1986; 61: 849-57.

13. Wasserman G, Graziano JH, Factor-Litvak P et al. Independent effects of lead exposure and iron deficiency anemia on developmental outcome at age 2 years. J Pediatr 1992; 121: 695-703.

14. Lozoff B, Jiménez E, Wolf AW. Long-term developmental outcome of infants with iron deficiency. N Engl J Med 1991; 325: 687-94.

15. Walter T, de Andracal I, Castillo M, Rivera F, Cobo C. Cognitive effect at 5 years of age in infants who were anemic at 12 months: a longitudinal study [abstract]. Pediatr Res 1990; 28: 295.

16. Idjradinata P, Pollitt E. Reversal of developmental delays in iron-deficient anaemic infants treated with iron. Lancet 1993; 341: 1-4.

17. Lozoff B, Wolf AW, Jiménez E. Iron-deficiency anemia and infant development: effects of extended oral iron therapy. J Pediatr 1996; 129: 382-9.

18. De Andraca I, Salas I, De la Parra A et al. Interacción madre-hijo y conducta del niño en preescolares con antecedentes de anemia por deficiencia de hierro. Arch Lat Nutr 1993; 43: 191-98.

19. Yip R, Walsh KM, Goldfarb MG et al. Declining prevalence of anemia in childhood in a middle-class setting: a pediatric success story? Pediatrics 1987; 80: 330-334.

20. Moffatt MEK, Longstaffe S, Besant J, Dureski C. Prevention of iron deficiency and psychomotor decline in high-risk infants through use of iron-fortified infant formula: A ramdomized clinical trial. J Pediatr 1994; 125: 527-34.

21. Skuse D, Pickles A, Wolke D, Reilly S. Postnatal growth and mental development: Evidence for a «sensitive period». J Child Psychol Psychiat 1994; 35: 521-45.