2008, Número 3
<< Anterior Siguiente >>
Bol Med Hosp Infant Mex 2008; 65 (3)
Asociación entre marcadores de inflamación sistémica de bajo grado e índice de masa corporal en niños con cáncer en quimioterapia
Herrera-Silva JC, Treviño-Moore A, Medina-Rosales H
Idioma: Español
Referencias bibliográficas: 35
Paginas: 167-168
Archivo PDF: 176.37 Kb.
RESUMEN
Introducción. Los marcadores de inflamación sistémica están catalogados como asociados al tumor. Objetivos: conocer y estimar el grado de asociación entre el índice de masa corporal (IMC) y marcadores de inflamación sistémica de bajo grado en niños con cáncer.
Métodos. Mediante una serie de casos se realizó la revisión de expedientes y mediciones corporales. Se consideraron variables antropométricas y bioquímicas de inflamación sistémica. El análisis de datos fue con estadística no paramétrica.
Resultados. Participaron 25 pacientes. No se encontró asociación entre IMC y marcadores de inflamación sistémica de bajo grado. La prevalencia global del síndrome inflamatorio fue de 72%. El fibrinógeno mostró correlación moderada con la proteína C reactiva (r =0.500) en neoplasias sólidas y hematológicas (r =0.621), y con la VSG en estas últimas (r =0.605).
Conclusiones. No existe asociación entre los marcadores de inflamación sistémica y el IMC en el grupo. La prevalencia del síndrome inflamatorio es muy alta.
REFERENCIAS (EN ESTE ARTÍCULO)
Baumann H, Gauldie J. The acute response. Immunol Today. 1994; 15: 74-80.
Gabay C, Kushner I. Acute-phase proteins other systemic responses to inflammation. N Engl J Med. 1999; 340: 448-50.
Wigmore SJ, Fearon KC, Maingay JP, Lai PB, Ross JA. Interleukin-8 can mediate acute-phase protein production by isolated human hepatocytes. Am J Phys. 1997; 273: E720-6.
Cavallo F, Di Carlo E, Butera M, Verrua A, Colombo M, Musían P, et al. Immune events associated with the cure of established tumors and spontaneous metastases by local and systemic interleukin-2. Cancer Res. 1999; 59: 414-21.
Fidler I. Angiogenesis and cancer metastases. Cancer J. 2000; 81: 134-41.
Mohamed-Ali V, Pinkney JH, Coppack SW. Adipose tissue as an endocrine and paracrine organ. Int J Obese Realt Metab Disord. 1998; 22: 1145-58.
Visser M, Bouter L, Maquillan GM, Tener MH, Harris TM. Elevated C-reactive protein levels in overweight and obese adults. JAMA. 1999; 282: 2131-5.
Visser M, Botuer L, Maquillan GM, Tener MH, Harris TM. Low-grade systemic inflammation in overweight children. Pediatrics. 2001; 107: 1-6.
Levent E, Goksen D, Ozyurek AR, Darcan S, Mahmut C, Coker M, et al. Stiffness of the abdominal aorta in obese children. J Pediatr Metab. 2002; 15: 405-9.
Desideri G, de Simona M, Lughetti L, Rosato T, Leéis ML, Marinucci MC, et al. Early activation of vascular endothelial cells and platelets in obese children. J Clin Endocrinol Metab. 2005; 90: 315-52.
Rohr SU, Fisberg M, Gonzaga TL. Nutritional assessment and serum zinc and copper concentration in leukemic children. Sao Paulo Med J. 1999; 117: 13-8.
Nysom K, Hola K, Michaelsen KF, Hertz H, Muller J, Molgaard C. Degree of fatness after treatment for acute lymphoblastic leukemia in childhood. J Clin Endocrinol Metab. 1999; 84: 4591-6.
Tarrella C, Caracciolo D, Gavarotii P, Argentino C, Sayillo F, Corradini P, et al. Overweight as an adverse prognostic factor for non-Hodgkin’s lymphoma patients receiving high-dose chemotherapy and auto graft. Bone Marrow Transplant. 2006; 26: 1185-91.
Weisberg SP, McCann D, Desai M, Rosenbaum M, Leíble RL, Ferrante QW Jr. Obesity in associated with macrophage accumulation in adipose tissue. J Clin Invest. 2003; 112: 1796-808.
Wisse BE. The inflammatory syndrome: The role of adipose tissue cytokines in metabolic disorders linked to obesity. J Am Soc Nephrol. 2004; 15: 2792-800.
Calzada-León R, Loredo-Abdalá A. Conclusiones de la reunión nacional de consenso sobre prevención, diagnóstico y tratamiento de la obesidad en niños y adolescentes. Bol Med Hosp Infant Mex. 2002; 59: 17-23.
MacDonald N. Cancer cachexia and targeting chronic inflammation: A unified approach to cancer treatment and palliative/supportive care. J Support Oncol. 2007; 5: 157-62.
Mahmoud FA, Rivera NI. The role of C-reactive protein as a prognostic indicator in advanced cancer. Curr Oncol Rep. 2002; 4: 250-5.
Pavey SJ, Hawson GAT, Marsh NA. Impact of the fibrinolytic enzyme system on prognosis and survival associated with non-small cell carcinoma. Blood Coagul Fibrinolysis. 2001; 12: 51-8.
Forrest LM, McMillam DC, Mc Ardle CS. Evaluation of cumulative prognostic scores based on the systemic inflammatory response in patients with inoperable non-small cell lung cancer. Br J Cancer. 2003; 89: 1028-30.
Walsh D, Mahmoud F, Barna B. Assessment of nutritional status and prognosis in advanced cancer: interleukin-6, C-reactive protein, ant the prognostic and inflammatory nutritional index. Support Care Cancer. 2003; 11: 60-2.
Yudkin JS, Stehouwer CD, Emeis JJ, Coppack SW. C-reactive protein in healthy subjects: associations with obesity, insulin resistance, and endothelial dysfunction: A potential role of cytokines originating from adipose tissue? Arterioscler Thromb Vasc Biol. 1999; 19: 972-8.
Guo SS, Chumlea WC, Roche AF, Siervogel RM. Age and maturity-related changes in body composition during adolescent into adulthood: The Fels Longitudinal Study. Int J Obes (Lond). 1997; 21: 1167-75.
Vanhala MJ, Vanhala PT, Keinanen-Kiukaanniemi SM, Kumpusalo EA, Takala JK. Relative weight gain and obesity as a child predict metabolic syndrome as an adult. Int J Obes (Lond). 1999; 23: 656-9.
Danesh J, Collins R, Appleby P, Peto R. Association of fibrinogen, C-reactive protein, albumin, or leukocyte count with coronary heart disease. JAMA. 1998; 279: 1477-82.
Ridker PM, Cushman M, Stampfer MJ, Tracy RP, Hennekens CH. Plasma concentration of C-reactive protein and the risk of future cardiovascular events among apparently healthy women. Circulation. 1998; 98: 731-3.
Cermak J, Key NS, Bach RR, Balla J, Jacob HS, Vercelloti GM. C-reactive protein induces human peripheral blood monocytes to synthesize tissue factor. Blood. 1993; 82: 513-20.
Parsons SK, Skapek SX, Neufeld EJ, Kuhlman C, Young ML, Donnelly M, et al. Asparaginase-associated Lipid abnormalities in children with acute lymphoblastic leukemia. Blood. 1997; 89: 1886-95.
Marinovic D, Dorgeret S, Lescoeur B, Alberti C, Noel M, Czernichow P, et al. Improvement in bone mineral density and body composition in survivors of childhood acute lymphoblastic leukemia: A 1-year prospective study. Pediatrics. 2005; 116: e102-e8.
Gunnell DJ, Frankel SJ, Nanchahal K, Peters TJ, Davey-Smith G. Childhood obesity and adult cardiovascular mortality: A 57-year follow-up study based on body mass index. Am J Clin Nutr. 1998; 67: 1111-8.
Argüelles B, Barrios V, Buño M, Madero L, Agente J. Anthropometric parameters and their relationship to serum growth hormone-binding protein and leptin levels in children with acute lymphoblastic leukemia: A prospective study. Eur J Endocrinol. 2000; 143: 243-50.
Wallace AM, Sattare N, Mc Millan DC. Effect of weight loss and the inflammatory response on leptin concentration in gastrointestinal cancer patients. Clin Cancer Res. 1998; 4: 2977-9.
Pietrobelli A, Faith MS, Allison DB, Gallagher D, Chiumello G, Heymsfield SB. Body mass index as a measure of adiposity among children and adolescent: A validation study. J Pediatr. 1998; 132: 204-10.
Amar MH, Friedman S, Hayat M, Somers R, Meerwaldt JH, Carde P, et al. Erythrocyte sedimentation rate predicts early relapse and survival in early-stage Hodgking´s disease. Ann Inter Med. 1991; 114: 361-5.
Ljungberg B, Grankvist K, Rasmuson T. Serum acute phase reactants and prognosis in renal cell carcinoma. Cancer. 1995; 76: 1435-9.