Miranda-Garduño LM, Reza-Albarrán A

Idioma: Español
Referencias bibliográficas: 40
Paginas: 36-46
Archivo PDF: 119.07 Kb.

RESUMEN

La integración de metabolismo e inmunidad bajo condiciones normales es benéfica para mantener la homeostasis, pero puede ser deletérea bajo condiciones de cambio metabólico como en la inmunosupresión característica de la desnutrición. Con el incremento del sobrepeso y la obesidad, nuevos problemas de la intersección del metabolismo e inmunidad han emergido: obesidad asociada a enfermedades inflamatorias, diabetes, hígado graso y aterosclerosis. Existe un alto nivel de coordinación entre las vías metabólica e inflamatoria y destacan en este sentido los macrófagos y los adipocitos en la obesidad. Las señales intracelulares activadas en la respuesta a la inflamación pueden inhibir la señal de la insulina. La pérdida de mediadores o moléculas de señalización inflamatorios previene la resistencia a la insulina. En ausencia de obesidad, una infusión de citocinas inflamatorias o lípidos causa resistencia a la insulina. Entender los mecanismos que conducen de obesidad a inflamación tendrá importantes implicaciones para reducir la morbilidad y mortalidad de la obesidad a través de prevenir su asociación con inflamación.

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