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1998, Número 2

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Vet Mex 1998; 29 (2)


Regiones genómicas asociadas con crecimiento en cerdos

Casas CE, Kirkpatrick BW

Idioma: Español/Inglés
Referencias bibliográficas: 86
Paginas: 181-189
Archivo PDF: 981.96 Kb.


RESUMEN

El objetivo del presente trabajo fue identificar los genes y las regiones genómicas que han sido asociadas con el crecimiento y las características a la canal en cerdos, así como su posible utilización e inclusión en programas de mejoramiento animal. Con el desarrollo de los marcadores genéticos se han identificado loci de características cuantitativas (LCC) asociados con crecimiento y características a la canal en cerdos. Las dos estrategias usadas para identificar LCC son el uso de los genes candidatos y las búsquedas genómicas. Combinando ambas estrategias se han identificado regiones genómicas en los cromosomas 3,4,5,6,7,12 y 13 potencialmente asociadas con el crecimiento y la grasa dorsal. Las regiones genómicas asociadas con características cuantitativas deben ser identificadas en cada población, ya que los LCC segregados en una población pueden estar fijos en otra; sin embargo, mientras siga existiendo la variación genética para la característica, los LCC se seguirán segregando y su identificación será posible. Es importante reconocer los LCC que afectan a la característica si se lleva a cabo la selección asistida con marcadores en una población.


REFERENCIAS (EN ESTE ARTÍCULO)

  1. Ensminger ME, Parker RO. Swine science (Animal Agriculture Series). 5th ed. Danville (IL): The Interstate Printers and Publishers Inc. 1984.

  2. Reeds PJ, Burrin DG, Davis TA, Fiorotto MA, Mersmann HJ, Pond WG. Growth regulation with particular referente to the pig. In: Hollis GR, editor. Growth of the pig. Bristol (UK): CAB International, 1993:1-32.

  3. Falconer DS. Introduction to quantitative genetics. 3rd ed. New York (NY): Longman Scientific and Technical, 1989.

  4. Geldermann H. Investigations on inheritance of quantitative characters in animals by gene markers. I. Methods. Theor Appl Genet 1975;46:319-330.

  5. Lande R. The minimum number of genes contributing to quantitative variation between and within populations. Genetics 1981;99:541-553.

  6. Archibald AL, Haley CS, Brown JF, Couperwhite S, McQueen HA, Nicholson D, et al. The PiGMaP consortium linkage map of the pig (Sus scrofa). Mamm Genome 1995;6:157-175.

  7. Ellegren H, Chowdhary BP, Johansson M, Marklund L, Fredholm M, Gustavsson I, et al. A primary linkage map of the porcine genome reveals a low rate of genetic recombination. Genetics 1994;137:1089-1100.

  8. Rohrer GA, Alexander LJ, Keele JW, Smith TP, Beattie CW. A microsatellite linkage map of the porcine genome. Genetics 1994;136:231-245.

  9. Rohrer GA, Alexander LJ, HuZ, Keele JW, Smith TP, Beattie CW. A comprehensive map of the porcine genome. Genome Res 1996;6:371-391.

  10. Bishop MD, Kappes SM, Keele JW, Stone RT, Sunden SL, Hawkins GA, et al. A genetic linkage map for cattle. Genetics 1994;136:619-639.

  11. Ma RZ, Beever JE, Da Y, Green CA, Russ I, Park C, et al. A male linkage map of the cattle (Bos taurus) genome. J Hered 1996;87:261-271.

  12. Kappes SM, Keele JW, Stone RT, McGraw RA, Sonstegard TS, Smith TPL, et al. A second-generation linkage map of the bovine genome. Genome Res 1997;7:235-249.

  13. Barendse W, Armitage SM, Kossarek LM, Shalom A, Kirkpatrick BW, Ryan AM, et al. A genetic linkage map of the bovine genome. Nat Genet 1994;6:227-235.

  14. Barendse W, Vaiman D, Kemp SJ, Sugimoto Y, Armitage SM, Williams JL, et al. A medium-density genetic linkage map of the bovine genome. Mamm Genome 1997;8:21-28.

  15. Dietrich WF, Miller JC, Steen RG, Merchant M, Damron D, Nahf R, et al. A genetic linkage map of the mouse with 4006 simple sequence length polymorphisms. Nat Genet 1994;7:220-245.

  16. Donis-Keller H, Green P, Helms C, Cartinhour S, Weiffenbach B, Stephens K, et al. A genetic linkage map of the human genome. Cell 1987;51:319-337.

  17. National Institute of Health Collaborative Mapping Group. A comprehensive human linkage map with centimorgan density. Science 1994;265:2049-2054.

  18. Crawford AM, Montgomery GW, Pierson CA, Brown T, Dodds KG, Sunden SLF, et al. Sheep linkage mapping: nineteen linkage groups derived from the analysis of paternal half-sib families. Genetics 1994;137:573-579.

  19. Broad TE, Hill DF. Mapping the sheep genome: practice, progress and promise. Br Vet J 1994;150:237-252.

  20. Cheng HH, Levin I, Vallejo RL, Khatib H, Dodgson JB, Crittenden LB, et al. Development of genetic map of the chicken with markers of high utility. Poultry Sci 1995;74:1855-1874.

  21. Kennedy BW, Verrinder-Gibbins AM, Gibson JP, Smith C. Coalescence of molecular and quantitative genetics for livestock improvement. J Dairy Sci 1990;73:2619-2627.

  22. McLaren DG, Fernando RL, Lewin HA, Schook LB. Integrated strategies and methodologies for the genetic improvement of animals. J Dairy Sci 1990;73:2647-2656.

  23. Haley CS. Livestock QTLs-bringing home the bacon? Trends Genet 1995;11:488-492.

  24. Dentine MR. Marker-assisted selection in cattle. Anim Biotech 1992;3:81-93.

  25. Schook LB, Clamp PA. Mapping genes for growth and development. In: Hollis GR, editor. Growth of the pig. Bristol (UK):CAB International, 1993:75-91.

  26. Beckmann JS, Soller M. Molecular markers in the genetic improvement of farm animals. Bio-Technol 1987;5:573-576.

  27. Rohrer GA. The candidate gene approach, a concept before its time? In: Paszek AA, Schook LB, Louis CF, Mickelson JR, Flickinger GH, Murtaugh J, et al., editors. First International Workshop on Porcine Chromosome 6. Anim Genet 1995;26:377-401.

  28. Sax K. The association of size differences with seed-coat pattern and pigmentation in Phaseolus vulgaris. Genetics 1923;8:552-560.

  29. Lander ES, Botstein D. Mapping Mendelian factors underlying quantitative traits using RFLP linkage maps. Genetics 1989;121:185-199.

  30. Darvasi A, Weinreb A, Minke V, Weller JI, Soller M. Detecting marker-QTL linkage and estimating QTL gene effect and map location using a saturated genetic map. Genetics 1993;134:943-951.

  31. Soller M, Brody T, Genizi A. On the power of experimental designs for the detection of linkage between marker loci and quantitative loci in crosses between inbred lines. Theor Appl Genet 1976;47:35-39.

  32. Haley CS, Knott SA. A simple regression method for mapping quantitative trait loci in line crosses using flanking markers. Heredity 1992;69:315-324.

  33. Andersson L, Haley CS, Ellegren H, Knott SA, Johansson M, Andersson J, et al. Genetic mapping of quantitative trait loci for growth and fatness in pigs. Science 1994;263: 1771-1774.

  34. Nielsen VH, Larsen NJ, Agergaad N. Association of DNA polymorphism in the growth hormone gene with basalplasma growth hormone concentration and production traits in pigs. J Anim Breed Genet 1995;112:205-212.

  35. Knorr C, Moser G, Muller E, Geldermann H. Association of GH gene variants with performance traits in F2 generations of European wild boar, Pietrain and Meishan pigs. Anim Genet 1997;28:124-128.

  36. Rothschild M, Jacobson C, Vaske D, Tuggle C, Wang L, Short T, et al. The estrogen receptor locus is associated with a major gene influencing litter size in pigs. Proc Nat Acad Sci USA 1996;93:201-205.

  37. Rathje TA, Rohrer GA, Johnson RK. Evidence for quantitative trait loci affecting ovulation rate in pigs. J Anim Sci 1997;75:1468-1494.

  38. Blattman AN, Gregory KE, Kirkpatrick BW. A search for quantitative trait loci for ovulation rate in cattle. Anim Genet 1996;27:157-162.

  39. Georges M, Nielsen D, Mackinnon M, Mishra A, Okimoto R, Pasquino AT, et al. Mapping quantitative trait loci controlling milk production in dairy cattle by exploiting progeny testing. Genetics 1995;139:907-920.

  40. Charlier C, Coppetiers W, Farnir F, Grobet L, Leroy PL, Michaux C, et al. The mh gene causing double-muscling in cattle maps to bovine chromosome 2. Mamm Genome1995;6:788-792.

  41. Cockett NE, Jackson SP, Shay TL, Nielsen D, Moore SS, Steele MR, et al. Chromosomal location of the callipyge gene in sheep (Ouis aries) using bovine DNA markers. Proc Nat Acad Sci USA 1994;91:3019-3023.

  42. Georges M, Dietz AB, Mishra A, Nielsen D, Sargeant LS, Sorensen A, et al. Microsatellite mapping of the gene causing Weaver disease in cattle will allow the study of an associated quantitative trait locus. Proc Nat Acad Sci USA 1993;90:1058-1062.

  43. Chua Jr SC, Chung WK, Wu-Peng XS, Zhang Y, Liu SM, Tartaglia L, et al. Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor. Science 1996;271:994-996.

  44. Davies JL, Kawaguchi Y, Bennett ST, Copeman JB, Cordell HJ, Pritchard LE, et al. A genome-wide search for human type 1 diabetes susceptibility genes. Nature 1994;371:130-136.

  45. Tomfohrde J, Silverman A, Barnes R, Fernandez-Vina MA, Young M, Lory D, et al. Gene for familial psoriasis susceptibility mapped to the distal end of human chromosome 17q. Science 1994;264:1141-1145.

  46. Plomin R, McClearn GE, Smith DL, Vignetti S, Chorney MJ, Chorney K, et al. DNA markers associated with high versus low IQ: the IQ quantitative trait loci (QTL) project. Behav Genet 1994;24:107-118.

  47. Hamer DH, Hu S, Magnuson VL, Hu N, Pattatucci AML. A linkage between DNA markers on the X chromosome and male sexual orientation. Science 1993;261:321-327.

  48. Sturtevant AH. A linear arrangement of six sex-linked factors in Drosophila, as shown by their mode of association. J Exp Zool 1913;14:43-59.

  49. Visscher PM, Haley CS. Utilizing genetic markers in pig breeding programmes. Anim Breed Abstr 1995;63:1-8.

  50. Casas-Carrillo E, Prill-Adams A, Price SG, Clutter AC, Kirkpatrick BW. Mapping genomic regions associated with growth rate in pigs. J Anim Sci 1997;75:2047-2053.

  51. O'Brien SJ, Peters J, Searle A, Womack J, Marshall-Graves J. Report of the committee on comparative gene mapping. Genome Prior Rep 1993;1:758-809.

  52. Clutter AC, Spicer LJ, Woltmann MD, Grimes RW, Hammond JM, Buchanan DS. Plasma growth hormone, insulin-like growth factor-I, and insulin-like growth factor binding proteins in pigs with divergent genetic merit for postweaning average daily gain. J Anim Sci 1995;73:1776.

  53. Yu TP, Tuggle CK, Schmitz CB, Rothschild MF. Association of PITl polymorphisms with growth and carcass traits in pigs. J Anim Sci 1995;73:1282-1288.

  54. Rothschild MF, Liu HC, Tuggle CK, Yu TP, Wang L. Analysis of pig chromosome 7 genetic markers for growth and carcass performance traits. J Anim Breed Genet 1995;112:341-348.

  55. Shimatsu A, Rotwein P. Mosaic evolution of the insulinlike growth factors. J Biol Chem 1987;262:7894-7900.

  56. Kirkpatrick BW. Identification of a conserved microsatellite site in the porcine and bovine insulin-like growth factor-I gene 5' flank. Anim Genet 1992;23:543-548.

  57. Casas-Carrillo E, Prill-Adams A, Price SG, Clutter AC, Kirkpatrick BW. Relationship of growth hormone and insulin-like growth factor-I genotypes with growth and carcass traits in swine. Anim Genet 1997;28:88-93.

  58. Collins AC, Martin ICA, Kirkpatrick BW. Growth and quantitative trait loci (QTL) on mouse chromosome 10 in a Quackenbush-Swiss x C57BL/6J backcross. Mamm Genome 1993;4:454-458.

  59. Horvat S, Medrano JF. Interval mapping of high growth (hg), a major locus that increases weight gain in mice. Genetics 1995;139:1737-1748.

  60. Moody DE, Pomp D, Newman S, MacNeil MD. Characterization of DNA polymorphisms in three populations of Hereford cattle and their associations with growth and maternal EPD in line 1 Hereford. J Anim Sci 1996;74:1784-1793.

  61. Clamp PA, Beever JE, Fernando RL, McLaren DG, Schook LB. Detection of linkage between genetic markers and genes that affect growth and carcass traits in pigs. J Anim Sci 1992;70:2695-2706.

  62. Clamp PA, Feltes R, Shalhevet D, Beever JE, Atac E, Schook LB. Linkage relationship between ALPL, ENOI, GPI, PGD and TGF§l on porcine chromosome 6. Genomics 1993;17:324-329.

  63. Aalhus JL, Jones SDM, Roberts WM, Tong AKW, Sather AP. Growth characteristics and carcass composition of pigs with known genotypes of stress susceptibility over a weight range of 70 to 120 kg. Anim Prod 1991;52:347-353.

  64. Sather AP, Murray AC, Zawadski SM, Johnson P. The effect of the halothane gene on pork production and meat quality reared under commercial conditions. Can J Anim Sci 1991;71:959-967.

  65. Pommier SA, Houde A, Rosseau F. Savoie Y. The effect of the malignant hyperthermia genotype as determined by a restriction endonuclease assay on carcass characteristics of commercial crossbred pigs. Can J Anim Sci 1992;72:973-976.

  66. Fujii J, Otsu K, Zorzato F, Deleon S, Khanna VK, Weiler JE, et al. Identification of a mutation in porcine ryanodine receptor associated with malignant hyperthermia. Science 1991;253:448-451.

  67. Vogeli P, Bolt R, Fries R, Stranzinger G. Co-segregation of the malignant hyperthermia and the Arg615-Cys615 mutation in the skeletal muscle calcium release channel protein in five European Landrace and Pietrain pig breeds. Anim Genet 1994;25 (Suppl 1):59-66.

  68. Harbitz I, Chowdhary B, Townsend PD. Assignment of the porcine calcium release channel gene, a candidate for the malignant hyperthermia locus, to the 6pll-q2I segment of chromosome 6. Genomics 1990;8:243-248.

  69. Ellegren H, Johansson M, Chowdhary BP, Marklund S, Ruter D, Marklund L, et al. Assignment of 20 microsatellite markers to the porcine linkage map. Genomics 1993;8:243-248.

  70. Paszek AA, Schook LB, Louis CF, Mickelson JR, Flickinger GH, Murtaugh J, et al. First international workshop on porcine chroinosome 6. Anim Genet 1995;26:377-401.

  71. Chung CS, Etherton TD, Wiggins JP. Stimulation of swine growth by porcine growth hormone. J Anim Sci 1985;60:118-130.

  72. Evock CM, Etherton TD, Chung CS, Ivy RE. Pituitary porcine growth hormone (pGH) and a recombinant pGH analog stimulate pig growth performance in a similar manner. J Anim Sci 1988;66:1928-1941.

  73. Hacker RR, Deschutter A, Adeola O, Kasser TR. Evaluation of long-term somatotropin implants in finishing pigs. J Anim Sci 1993;71:564-570.

  74. Lee KC, Azain MJ, Hardin MD, Williams SE. Effect of porcine somatotropin (pST) treatment and withdrawal on performance and adipose tissue cellularity in finishing swine. J Anim Sci 1994;72:1702-1711.

  75. Vize PD, Wells JRE. Isolation and characterization of the porcine growth hormone gene. Gene 1987;55:339-344.

  76. Thomsen PD, Fredholm M, Christensen K, Schwerin M. Assignment of the porcine growth hormone gene to chromosome 12. Cytogenet Cell Genet 1990;54:92-94.

  77. Kirkpatrick BW, Huff BM, Casas-Carrillo E. Double strand DNA conformation polymorphisms as a source of highly polymorphic genetic markers. Anim Genet 1993;24:155-161.

  78. Larsen NJ, Ellegren H, Brauner-Nielsen P, Andersson L. Genetic variation at the growth hormone locus in a wild pig intercross; test of association to phenotypic traits and linkage to the blood group D locus. Theor Appl Genet 1995;91:1074-1077.

  79. Salmon RK, Berg RT, Yeh FC, Hodgetts RB. Identification of a variant growth hormone haplotype in mice selected for high body weight. Genet Res Camb 1988;52:7-15.

  80. Winkelman DC, Hodgetts RB. RFLPs for somatotropic genes identify quantitative trait loci for growth in mice. Genetics 1992;131:929-937.

  81. Nielsen VH, Bjerre AE. Growth hormone gene polymorphism in lines of mice selected for growth on two diets. Proceedings of the 5th World Congress on Genetics Applied to Livestock Production, 1994 August 7-12; Guelph, Canada. Guelph, Canada: Organizing Committee of the 5th World Congress on Genetics Applied to Livestock Production, 1994;21:288-290.

  82. Rocha JL, Baker JF, Womack JE, Sanders JO, Taylor JF. Statistical associations between restriction fragment length polymorphisms and quantitative traits in beef cattle. J Anim Sci 1992;70:3360-3370.

  83. Pilla AM, Napolitano F, Moioli BM, Puppo S, Pilla F, Carreta A. Association between restriction fragment length polyinorphisms and quantitative traits in Piedmontese x Chianina crossbred. Proceedings of the 5th World Congress on Genetics Applied to Livestock Production; 1994 August 7-12; Guelph, Canada. Guelph, Canada: Organizing Committee of the 5th World Congress on Genetics Applied to Livestock Production, 1994;21:284-287.

  84. Fotouhi N, Karatzas CN, Kuhnlein U, Zadworny D. Identification of growth hormone DNA polymorphisms which respond to divergent selection for abdominal fat content in chickens. Theor Appl Genet 1993;85:931-936.

  85. Kuhnlein U, Ni L, Weiagend S, Gavora JS, Fairfull W, Zadworny D. DNA polymorphisms in the chicken growth hormone gene: response to selection for disease resistance and association with egg production. Anim Genet 1997;28:116-123.

  86. Tuggle CK, Yu TP, Helm J, Rothschild MF. Cloning and restriction fragment length polymorphism analysis of cDNA for swine PIT-1, a gene controlling growth hormone expression. Anim Genet 1993;24:17-21.




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