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2007, Número 2

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Gac Med Mex 2007; 143 (2)


El ciclo celular y su papel en la biología de las células progenitoras hematopoyéticas

Alvarado-Moreno JA, Mayani H

Idioma: Español
Referencias bibliográficas: 107
Paginas: 149-161
Archivo PDF: 263.06 Kb.


RESUMEN

El ciclo celular constituye el conjunto de eventos que determinan la actividad metabólica de toda célula así como su división y la generación de células hijas. Este proceso está involucrado en todos los procesos celulares tales como proliferación y diferenciación. Se ha demostrado que diversos elementos moleculares participan en su regulación y que alteraciones en este proceso pueden conducir a trastornos fisiológicos e incluso a la muerte del organismo. En los mamíferos, uno de los tejidos con mayor recambio celular es el hematopoyético, por lo que se requiere un control muy estricto del ciclo celular, principalmente a nivel de células troncales y progenitoras para la óptima producción de células sanguíneas. En este artículo presentamos un panorama general de los principales mecanismos y factores involucrados en la regulación del ciclo celular, poniendo particular énfasis en su papel en la biología de las células hematopoyéticas primitivas.


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