Amaya GM, Barba F, Blancas GF, Gómez FM, Gómez TA, González SR, Hojyo TMT., León DG, López IMM, Moncada B, Orozco TR, Santamaría V

Idioma: Español
Referencias bibliográficas: 53
Paginas: 172-184
Archivo PDF: 151.28 Kb.

RESUMEN

La psoriasis es una enfermedad crónica, mediada inmunológicamente, de etiología desconocida, susceptible de control mediante tratamiento médico prolongado, no curable, con grados diferentes de afectación que se caracteriza en la mayoría de las veces por la presencia predominante y característica de lesiones eritematoescamosas. Pueden presentarse manifestaciones y afectación articular, situación que se conoce como artritis psoriásica. Entre el 25% y 35% de los pacientes el cuadro clínico puede ser de moderado a severo. La psoriasis afecta la calidad de vida de los pacientes que la sufren, lo cual se relaciona con la extensión de la afectación y la intensidad de las manifestaciones clínicas. También es capaz de producir en diferentes grados de afectación y discapacidad física. Los tratamientos hasta hace poco tiempo utilizados en forma escalonada son la fototerapia, los medicamentos de aplicación local o tópica y los sistémicos. En los casos moderados a severos la estrategia terapéutica considera la combinación de ellos, o incluso las tres modalidades. Con el desarrollo de investigación en biología molecular y tecnología ha surgido la denominada terapia biológica. La terapia biológica ha sido diseñada para modular los pasos claves en la patogénesis de la psoriasis. La terapia biológica ha sido evaluada en pacientes con psoriasis con beneficios significativos con perfiles de tolerabilidad y seguridad satisfactorios, tanto a escala internacional como nacional. La limitación que la terapia biológica presenta dentro de las estrategias de tratamiento es definitivamente su costo. En el ámbito nacional además de su costo, es la escasa divulgación de la experiencia desarrollada por especialistas con su uso, y finalmente la incorporación de la terapia biológica en guías clínicas y lineamientos de tratamiento para psoriasis.

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