2007, Número 3
<< Anterior Siguiente >>
Arch Cardiol Mex 2007; 77 (3)
Predictores de mortalidad y mal pronóstico en pacientes ancianos y de alto riesgo que van a ser sometidos a intervención coronaria percutánea
Miranda ME, Peña DMA, Castellanos J, Exaire E, Arrieta O, Salazar DE, Villavicencio FR, Delgadillo-Rodríguez H, González-Quesada CJ, Martínez-Ríos MA
Idioma: Ingles.
Referencias bibliográficas: 26
Paginas: 194-199
Archivo PDF: 95.62 Kb.
RESUMEN
Propósito: Identificar predictores de mortalidad y de eventos cardiovasculares adversos mayores (ECAM) intrahospitalarios y a largo plazo (›1 año) en ancianos sometidos a intervencionismo coronario.
Métodos: Se incluyeron 73 pacientes (≥ 80 años). Se obtuvieron retrospectivamente características clínicas y del intervencionismo. Los desenlaces primarios fueron mortalidad intrahospitalaria y a largo plazo, así como un desenlace compuesto de infarto del miocardio no fatal, revascularización de vaso tratado, cirugía de revascularización coronaria y muerte (ECAM).
Resultados: 83% de los pacientes tuvieron síndrome coronario agudo o Infarto agudo del miocardio, 43% eran trivasculares, 42% presentaban insuficiencia cardíaca. La mortalidad y ECAM intrahospitalarios fueron de 16.4% y 19%, respectivamente. Mortalidad y ECAM a largo plazo fueron de 11.3% y 16.4% respectivamente. Las características que se asociaron a mortalidad y ECAM intrahospitalarios fueron clasificación de Killip III-IV, insuficiencia cardíaca, choque cardiogénico, flujo TIMI 0-2 pre y post procedimiento, diabetes mellitus, nefropatía por contraste, presencia de bloqueo A-V o fibrilación auricular (FA). Los predictores de mortalidad a largo plazo fueron insuficiencia cardíaca, diabetes mellitus, flujo TIMI 0-2 antes y después de la intervención y bloqueo A-V o FA.
Conclusiones: La identificación de estos factores de riesgo puede ayudar a predecir complicaciones en pacientes de edad avanzada.
REFERENCIAS (EN ESTE ARTÍCULO)
Wenger NK, O’Rourke RA, Marcus FI: The care of elderly patients with cardiovascular disease. Ann Intern Med. 1988; 109(5): 425-8.
Grines CL, Browne KF, Marco J, Rothbaum D, Stone GW, O’Keefe J, et al: A comparison of immediate angioplasty with thrombolytic therapy for acute myocardial infarction. The Primary Angioplasty in Myocardial Infarction Study Group. N Engl J Med 1993; 328(10): 673-9.
Guagliumi G, Stone GW, Cox DA, Stuckey T, Tcheng JE, Turco M, et al: Outcome in elderly patients undergoing primary coronary intervention for acute myocardial infarction: results from the Controlled Abciximab and Device Investigation to Lower Late Angioplasty Complications (CADILLAC) trial. Circulation 2004; 110(12): 1598-604.
Pfisterer M, Buser P, Osswald S, Allemann U, Amann W, Angehm W, et al: Outcome of elderly patients with chronic symptomatic coronary artery disease with an invasive vs optimized medical treatment strategy: one-year results of the randomized TIME trial. JAMA 2003; 289(9): 1117-23.
Peterson ED, Alexander KP, Malenka DJ, Hannan EL, O’Conner GT, McCallister BD: Multicenter experience in revascularization of very elderly patients. Am Heart J 2004; 148(3): 486-92.
Barakat K, Wilkinson P, Deaner A, Fluck D, Ranjadayalan K, Timmis A: How should age affect management of acute myocardial infarction? A prospective cohort study. Lancet 1999; 353(9157): 955-9.
Batchelor WB, Anstrom KJ, Muhlbaier LH, Grosswald R, Weintraub WS, O’Neil WW, et al: Contemporary outcome trends in the elderly undergoing percutaneous coronary interventions: results in 7,472 octogenarians. J Am Coll Cardiol 2000; 36(3): 723-30.
Graham MM, Ghali WA, Faris PD, Galbraith PD, Norris CM, Knudtson ML: Survival after coronary revascularization in the elderly. Circulation 2002; 105(20): 2378-84.
Gurwitz JH, Col NF, Avorn J: The exclusion of the elderly and women from clinical trials in acute myocardial infarction. JAMA 1992; 268(11): 1417-22.
Lee PY, Alexander KP, Hammill BG, Pasquali SK, Peterson ED: Representation of elderly persons and women in published randomized trials of acute coronary syndromes. JAMA 2001; 286(6): 708-13.
TIMI Study Group. The Thrombolysis in Myocardial Infarction (TIMI) trial. Phase I findings. N Engl J Med 1985; 312(14): 932-6.
Hochman JS, Sleeper LA, Webb JG, Sanborn TA, White HD, Talley JD, et al: Early revascularization in acute myocardial infarction complicated by cardiogenic shock. SHOCK Investigators. Should We Emergently Revascularize Occluded Coronaries for Cardiogenic Shock. N Engl J Med 1999; 341(9): 625-34.
Sarnak MJ, Levey AS, Schoolwerth AC, Coresh J, Culleton B, Hamm LL, et al: Kidney disease as a risk factor for development of cardiovascular disease: a statement from the American Heart Association Councils on Kidney in Cardiovascular Disease, High Blood Pressure Research, Clinical Cardiology, and Epidemiology and Prevention. Circulation 2003; 108(17): 2154-69.
Levey AS, Coresh J, Balk E, Karusz AT, Levin A, Steffes MW, et al: National Kidney Foundation practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Ann Intern Med 2003; 139(2): 137-47.
Mann JF, Gerstein HC, Pogue J, Bosch J, Yusuf S: Renal insufficiency as a predictor of cardiovascular outcomes and the impact of ramipril: the HOPE randomized trial. Ann Intern Med 2001; 134(8): 629-36.
Beddhu S, Allen-Brady K, Cheung AK, Horne BD, Bair T, Muhlestein JB et al: Impact of renal failure on the risk of myocardial infarction and death. Kidney Int 2002; 62(5): 1776-83.
Shlipak MG, Fried LF, Crump C, Bleyer AJ, Manolio TA, Tracy RP, et al: Cardiovascular disease risk status in elderly persons with renal insufficiency. Kidney Int 2002; 62(3): 997-1004.
Edwards MS, Craven TE, Burke GL, Dean RH, Hansen KJ: Renovascular disease and the risk of adverse coronary events in the elderly: a prospective, population-based study. Arch Intern Med 2005; 165(2): 207-13.
Anavekar NS, McMurray JJ, Velazquez EJ, Solomon SD, Kober L, Rouleau JL, et al: Relation between renal dysfunction and cardiovascular outcomes after myocardial infarction. N Engl J Med 2004; 351(13): 1285-95.
Abidov A, Kaluski E, Hod H, Leor J, Vered Z, Gottlieb S, et al: Influence of conduction disturbances on clinical outcome in patients with acute myocardial infarction receiving thrombolysis (results from the ARGAMI-2 study). Am J Cardiol 2004; 93(1): 76-80.
Lehto M, Snapinn S, Dickstein K, Swedberg K, Nieminen MS: Prognostic risk of atrial fibrillation in acute myocardial infarction complicated by left ventricular dysfunction: the OPTIMAAL experience. Eur Heart J 2005; 26(4): 350-6.
Meine TJ, Al-Khatib SM, Alexander JH, Granger CB, White HD, Kilaru R, et al: Incidence, predictors, and outcomes of high-degree atrioventricular block complicating acute myocardial infarction treated with thrombolytic therapy. Am Heart J 2005; 149(4): 670-4.
Holmes DR, Jr., White HD, Pieper KS, Ellis SG, Califf RM, Topol EJ: Effect of age on outcome with primary angioplasty versus thrombolysis. J Am Coll Cardiol 1999; 33(2): 412-9.
DeGeare VS, Stone GW, Grines L, Brodie BR, Cox DA, Garcia E, et al: Angiographic and clinical characteristics associated with increased in-hospital mortality in elderly patients with acute myocardial infarction undergoing percutaneous intervention (a pooled analysis of the primary angioplasty in myocardial infarction trials). Am J Cardiol 2000; 86(1): 30-4.
Carnendran L, Abboud R, Sleeper LA, Gurunathan R, Webb JG, Menon V, et al: Trends in cardiogenic shock: report from the SHOCK Study. The should we emergently revascularize Occluded Coronaries for cardiogenic shock? Eur Heart J 2001; 22(6): 472-8.
Mehta RH, Sadiq I, Goldberg RJ, Gore JM, Avezum A, Spencer F, et al: Effectiveness of primary percutaneous coronary intervention compared with that of thrombolytic therapy in elderly patients with acute myocardial infarction. Am Heart J 2004; 147(2): 253-9.