Casas RML, Zúñiga RA, Pasquetti CA, Meléndez MG

Idioma: Español
Referencias bibliográficas: 27
Paginas: 136-141
Archivo PDF: 127.23 Kb.

RESUMEN

La sepsis, como resultado de la agresión externa y la respuesta a ella, conlleva alteraciones metabólicas que implican aumento del recambio de glucosa, e incremento de gluconeogénesis. El catabolismo del músculo durante la sepsis es consecuencia tanto de estimulación de proteólisis como de inhibición de la síntesis de proteínas, mediadas por interacción hormonal (insulina, factor de crecimiento tipo insulina, glucocorticoides) y de citocinas (factor de necrosis tumoral, interleucina-1) además por deficiencia de sustratos. Todo ello produce pérdida de proteínas corporales mayor de 0.5 g/kg/día. Las terapias actuales están enfocadas a reducir el catabolismo proteínico muscular y promover el aumento de la masa magra, para lo que se han utilizado infusiones de insulina, hormona del crecimiento, factor de crecimiento tipo insulina, bloqueadores de proteasomas, glutamina y bloqueadores de factor de necrosis tumoral.

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