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2007, Número 1

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Rev Mex Patol Clin Med Lab 2007; 54 (1)


Alteraciones histológicas a nivel pulmonar inducidas por Mycoplasma fermentans

Román-Méndez C, Santellán-Olea MR, Cedillo-Ramírez L, Rivera-Tapia JA

Idioma: Español
Referencias bibliográficas: 32
Paginas: 40-46
Archivo PDF: 139.06 Kb.


RESUMEN

Antecedentes: Está documentado que diversas especies de micoplasmas son causa importante de morbilidad y mortalidad por neumonía en humanos y modelos animales. Objetivo: Determinar las lesiones en tracto respiratorio causadas por Mycoplasma fermentans. Material y métodos: Dieciocho hámsters recibieron vía intratraqueal cultivo de Mycoplasma fermentans a una concentración de 106 UFC y fueron sacrificados tres ejemplares los días 5, 15, 30, 60, 80 y 120 posinoculación. Se obtuvieron muestras de suero para la detección de anticuerpos contra Mycoplasma fermentans por medio de la técnica de inhibición metabólica. Los pulmones se extrajeron para el aislamiento por cultivo y el estudio histológico. Resultados: La detección de anticuerpos resultó negativa en el total de las muestras. Mycoplasma fermentans persistió en tracto respiratorio durante todo el experimento y los hámsters infectados mostraron evidencia histológica de inflamación pulmonar. Los micoplasmas colonizan de forma primaria mucosas, entablando una asociación con las células epiteliales de su hospedero, usualmente en tracto urogenital o respiratorio. Los modelos animales han permitido investigar la participación de los micoplasmas en condiciones crónicas pulmonares, además de revelar los aspectos histopatológicos de la enfermedad pulmonar.


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