2004, Número 1
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Alerg Asma Inmunol Pediatr 2004; 13 (1)
Citocinas y otras moléculas involucradas en sepsis y en pacientes con sepsis y complicaciones de neutropenia
Guzmán CB, Correa BD, Caballase UE, Calderón C
Idioma: Español
Referencias bibliográficas: 31
Paginas: 15-23
Archivo PDF: 108.76 Kb.
RESUMEN
La neutropenia es un factor importante de riesgo para sepsis en pacientes con cáncer. La morbi-mortalidad en la sepsis, ha correlacionado directamente con niveles elevados de citocinas. Se ha demostrado elevación de algunos de estos factores en neutropenia y sepsis, con valor diagnóstico.
REFERENCIAS (EN ESTE ARTÍCULO)
Chanock S, Pizzo P. Infectious Disease Emergencies: Fever in the Neutropenic Host. Infect Dis Clin North Am 1996; 10(4): 762-78.
Pizzo P. Management of fever in patients with cancer and treatment induced neutropenia. N Engl J Med 1993; 328: 1323-35.
Cebon J, Layton JE, Maher D, Morstyn G, et al. Endogenous haemopoietic growth factors in neutropenia and infection. B J Haematol 1994; 86: 265-73.
Damas P, Canivet J, De Groote D et al. Sepsis and serum cytokine concentrations. Crit Care Med 1997; 25(3): 405-412.
Abraham E, Matthay M, Dinarello C et al. Consensus conference definitions for sepsis, septic shock, acute lung injury, and acute respiratory distress syndrome: Time for a reevaluation. 2000; 28(1): 232-37.
Abbas A, Lichtman A, Pober J. Inmunología Celular y Molecular. Interamericana, 1995: 4, 10, 268-91, 308-10, 329-32.
Fleisher T, Bleesing J. Primary Immune deficiencys: presentation, diagnosis and management. Immune function. Ped Clin North Am 2000; 47(6): 295-306.
Reinhart K. Markers of endotelial damage in organ dysfunction and sepsis. Crit Care Med 2002; 30(5 Suppl): 302-12.
Hack C, Zeerlerder S. The endothelium in sepsis: source of and a target of inflammation. Crit Care Med 2001; 29(7): 294-310.
Marshall J. Inflammation, coagulopathy, and the pathogenesis of multiple organ dysfunction syndrome. Crit Care Med 2000; 29(7): 1323-36.
Kayak S. Elevated circulating E selectin, intercellular adhesion molecule 1, and von Willebrand factor in patients with severe infection. American Journal of Respiratory and Crit Care Med 1998; 157(3): 776-84.
Mesters R, Helterbrand J, Utterback B et al. Prognostic values of protein C concentrations in neutropenic patients at high risk of severe septic complications. Crit Care Med 2000; 28(7): 2209-16.
Harbarth S, Holeckova K, Froidevaux C, Pittet D. Diagnostic value of procalcitonin, interleukin 6, and interleukin 8 in critically ill patients admitted with suspected sepsis. American Journal of Respiratory and Crit Care Med 2001; 164(3): 396-402.
Boucher BA. Procalcitonin: Clinical tool or laboratory curiosity? Crit Care Med 2000; 28(4): 1224-32.
Lehrnbecher Th, Venzon D, De Haas M, Chanock S. Assesment of Measuring Circulating levels of interleukin 6, Interleukin 8, C reactive protein, Soluble FC gamma receptor type III, and Mannose Binding protein in febrile children with cancer and neutropenia. Clin Infect Dis 1999; 29: 414-419.
Taniguchi T, Koido Y, Jyunichi A et al. Change in the ratio of interleukin 6 to interleukin 10 predicts a poor outcome in patients with systemic inflammatory response syndrome. Crit Care Med 1999; 27(7): 1262-65.
Borreli E, Roux P, Grau G et al. Plasma concentrations of cytokines, their soluble receptors and antioxidant vitamins can predict the development of multiple organ failure in patients at high risk. Crit Care Med 1996; 24(3): 227-42.
Rintala E. Endotoxin, interleukin 6 and phospholipase A2 as markers of sepsis in patients with hematological malignancies. Scand J Infect Dis 1995; 27(1): 39-43.
Friedland J, Daryanani J, Bland J et al. Plasma proinflammatory cytokine concentrations, Acute Physiology and Chronic Health Evaluation (APACHE) III scores and survival in patients in an intensive care unit. Crit Care Med 1996; 24(11): 1775-82.
Barriere S, Lowry S. An overview of mortality risk prediction in sepsis. Crit Care Med 1995; 23(2): 376-95.
Dinarello CH. Proinflammatory and anti-inflammatory cytokines as mediators in the pathogenesis of Septic Shock. Chest 1997; 112(6): 329-332.
Presneill J, Waring P, Layton J et al. Plasma Granulocyte colony- stimulating factor levels in critical illness including sepsis and septic shock: Relation to disease severity, multiple organ dysfunction and mortality. Crit Care Med 2000; 28(7): 587-96.
Nelson S, Bagby G. Granulocyte Colony-Stimulating factor and modulation of inflammatory cells in sepsis. Clin Chest Med 1996; 17(2): 319-32.
Whalen D. Contrarregulatory control of the acute inflammatory response: Granulocyte colony-stimulating factor has anti-inflammatory properties. Crit Care Med 1999; 27(5): 1999, 1019-21.
Kim S, Demetri G et al. Haematologic Complications of Cancer, Chemotherapy and Neutropenia. Haematol/Oncol Clin North Am 1996; 10(2): 377-95.
Gross-Weege W, Dumon K, Dahmen A. Granulocyte colony-stimulating factor (G-CSF) serum levels in surgical intensive care patients. Infection 1997; 25: 213-16.
Dhainaut J. Hepatic response to sepsis: interaction between coagulation and inflammatory processes. Crit Care Med 2001; 29(7): 1632-47.
Shorr A, Thomas S, Alkins S et al. D-dimer correlates with proinflammatory cytokine levels and outcome in Critically Ill Patients. Chest 2002; 121(4): 1024-1036.
Mesters RM, Manucci PM, Coppola R et al. Factor VIIa and antitrombin III activity during severe sepsis and septic shock in neutropenic patients. Blood 1996; 88: 881-886.
Nawroth P, Stern D. Modulation of endotelial cell hemostatic properties by tumor necrosis factor. J Exp Med 1986; 163(3): 740-45.
Zimmerman G, McIntyre T, Prescott S. The platelet-activating factor signaling system and its regulators in syndromes of inflammation and thrombosis. Crit Care Med 2000; 30(5): 758-72.