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Diario Oficial de la Sociedad Mexicana de Cirugía Cardiaca, A.C., y del Colegio Mexicano de Cirugía Cardiovascular y Torácica, A.C.

2024, Número 3

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Cir Card Mex 2024; 9 (3)


Un sistema anticalcificante. Una opción contra la calcificación de las bioprótesis

Juárez-Hernández A, Masso-Rojas FA

Idioma: Ingles.
Referencias bibliográficas: 49
Paginas: 79-86
Archivo PDF: 335.58 Kb.


RESUMEN

Las bioprótesis cardiacas son en la actualidad la mejor opción para sustituir una válvula cardiaca enferma. Desde hace varios años se sabe que el principal problema de las bioprótesis es la calcificación (mineralización). Por tanto, en nuestra institución, donde se tiene ya experiencia de 35 años en la elaboración de bioprótesis, se investigó y desarrolló un sistema para tratar de proteger nuestras bioprótesis de este problema. Nuestras prótesis originalmente se hicieron con duramadre y posteriormente con pericardio bovino preservadas con glutaraldehído, solución que prepara bien al tejido biológico, pero que tiene el inconveniente de atraer calcio. El sistema propuesto y probado fue el de agregar un aminoácido sencillo, glicina, al tratamiento general. Este tratamiento impide la adhesión de calcio al tejido biológico, permitiéndole un tiempo de vida funcional más prolongado que con el tratamiento convencional. A partir de estudios in vitro e in vivo muy satisfactorios, se pasó a la etapa clínica, en donde hasta el momento se han implantado 1,362 prótesis en todas las posiciones con excelentes resultados a 10 años.


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