2003, Número 3
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Gac Med Mex 2003; 139 (3)
Fisiopatología de las complicaciones vasculares del pie diabético
Arana-Conejo V, Méndez-F JD
Idioma: Español
Referencias bibliográficas: 74
Paginas: 255-264
Archivo PDF: 86.37 Kb.
RESUMEN
Objetivo: Revisar la literatura sobre los avances de la investigación científica en el área de las complicaciones vasculares del pie diabético con especial atención en las lesiones ulcerativas y los enfoques de su prevención y tratamiento.
Materiales: Se hizo una revisión de los artículos más relevantes sobre este tema publicados entre 1980 y 2001, que se obtuvieron por una búsqueda en la base de datos MEDLINE.
Resultados: Los mecanismos fisiológicos y bioquímicos que regulan el funcionamiento coordinado de la circulación sanguínea y de la pared vascular se encuentran alterados en los vasos sanguíneos grandes y pequeños en la diabetes mellitus. Las alteraciones vasculares observadas en los pacientes diabéticos dan lugar a la enfermedad vascular periférica que en estos pacientes muestra características especiales y que condicionan una mayor predisposición a lesiones ulcerativas en el pie con tendencia a la cronicidad y una menor capacidad de reparación que en pacientes no diabéticos. Estas lesiones con frecuencia terminan en amputación de la extremidad inferior. No obstante los esfuerzos realizados para prevenir y tratar estas complicaciones, no se han obtenido resultados satisfactorios.
Conclusiones: Es necesario investigar nuevos enfoques de prevención y tratamiento de las complicaciones vasculares del pie diabético que den especial importancia a los mecanismos fisiológicos y bioquímicos alterados de la diabetes mellitus.
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