2006, Número 1
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Cir Plast 2006; 16 (1)
Cicatrización en el neonato con labio y paladar hendidos
Sánchez CJ
Idioma: Español
Referencias bibliográficas: 25
Paginas: 24-27
Archivo PDF: 88.35 Kb.
RESUMEN
La antigua regla de los 10, seguida por muchos autores como norma desde 1966, como parámetro general para el inicio del tratamiento de los pacientes con labio hendido, ha sido un paradigma que se debe cuestionar a la luz de los conocimientos actuales. Ahora se sabe que las heridas sufridas por un producto durante la gestación antes de las 24 semanas, sanan sin dejar cicatriz. Se sabe además que sobre este tema toda la atención se ha enfocado al periodo pre-transicional de la cicatrización fetal, pero ahora se pueden aplicar prácticamente algunos conocimientos probados que permiten transpolarlos a los pacientes con labio hendido para mejorar las cicatrices resultantes. Se presenta una revisión de la bibliografía sobre este concepto y se discuten sus posibles aplicaciones prácticas en futuros pacientes.
REFERENCIAS (EN ESTE ARTÍCULO)
Lorenz HP, Longaker MT, Perkocha LA et al. Scarless wound repair; a human fetal skin model. Development 1992; 114: 253-259.
Cass DL, Bullard KM, Silvestre KG et al. Wound size and gestational age modulate scar formation in fetal wound repair. J Pediatr Surg 1997; 32: 411-5.
McCallion RL, Ferguson MWJ. Fetal wound healing and the development of antiscarring therapies for adult wound healing. In: Clark RAF (ed). The molecular and cellular biology of wound repair. Vol XXIII New York: Plenum Press; 1996: 561-600.
Monasterio FO, Benavides A, Salazar A et al. Intrauterine cleft lip surgery. Perspectivas in Plast Surg 1990; 4 (2); 1-11.
Avery GB, Fletcher MA, MacDonald MG. Neonatología. Fisiología y manejo del recién nacido. 2004; 418-430.
Wilhelmsen HR, Musgrave RH. Complications on Cleft lip Surgery. Cleft Palate J 1966; 3: 223-231.
DanC, Ting K, Soo C et al. Clinical fetal wound healing. Curr Persp Plast Surg 2003; 30: 13-23.
Jennings RW, Adzick JR, Longaker MT el al. Ontogeny of fetal sheep polymorphonuclear leukocyte phagocitosis. J Pediatr Surg 1991; 26: 853-5.
Hallock GG, Merkel JR, Rice DC et al. The ontogeny transition of collagen deposition in rat skin. Ann Plast Surg 1993; 30: 239-43.
Chandrakasan G, Rutka J, Stern R. Hyaluronic acid stimulates collagen synthesis and levels of type III collagen in cultures of human fibroblasts. J Cell Biol 1986; 103: 252.
Mast BA, Diegelmann RF, Krumel TM et al. Hyaluronic acid modulates proliferation of collagen and protein synthesis of cultured fetal fibroblasts. Matrix 13: 441-6.
Beanes SR, Dang C, Soo C el al. Down regulation of decorin, a transforming growth factor beta modulator is associated with scarless fetal wound healing. J Pediatr Surg 2001; 11: 1666-71.
Beanes SR, Dang C, Soo C et al. Ontogenic transition in the fetal wound extracellular matrix correlates with scar formation. Wound Repair Regen 2001; 9: 151.
Lorenz HP, Sooc, Beanes SR et al. Differential expression of matrix metalloproteinases and their tissue derivated inhibitors in scarless wound healing. Surg Forum 2001; 52: 397-8.
Peled ZM, Phelps ED, Updike D et al. Matrix metalloproteinases and the ontogenic of scarless repair: the other side of wound healing balance. Plast Reconstr Surg 2002; 110: 801-11
Cromack DT, Spon MB, Roberts AB et al. Transforming growth factor beta levels in rat wound chambers. J Surg Res 1987; 42: 622-8.
Sporn MB, Roberts AB, Shull JH et al. Polypeptide transforming growth factors isolated from bovine sources and used for wound healing in vivo. Science 1983; 1219: 1329-31.
Nath RK, LaRegina M, Markham H et al. The expression of transforming growth factor type beta in fetal and adult rabbit skin wounds. J Pediat Surg 1944; 29: 416-21.
Dang C, Beanes SR, Soo C et al. A high ratio of TGF-33 to TGF-31 expression in wounds is associated with scarless repair. Wound Repair Regener 2001; 9: 153.
Whitby DJ, Ferguson MWJ. Immunohistochemical localization of growth factors in fetal wound healing. Dev Biol 1991; 147: 207-15.
Dang CM, Beanes SR, Soo C et al. Decreased expression of fibroblast and Keratinocyte growth factor isoforms and receptors during scarless repair. Plast Reconstr Surg In Press.
Constant JS, Bullard KM, Hunt TK et al. Increased vascular endothelial growth factor in hypoxid fetal wounds. Surg Forum 1997; 48: 519-21.
Liechty KW, Adzic NS, Crombeholme TM. Diminished interleukin 6 (IL-6) production during scarless human fetal wound repair. Cytokine 2000; 12: 671-6.
Lietchty KW, Crombeholme TM, Cass DL et al. Diminished interleukin 8 (IL-8) production in fetal wound healing response. J Surg Res 1998; 77: 80-4.
Gordon AD, Karmacharya J, Herlyn M et al. Scarless wound healing induced by adenoviral-mediatic over expression of interleukyne 10. Surg Forum 2001; 52: 658-9.