Madrigal-Jiménez HM, Flores-Flores L, Carrillo EF, Zúñiga-Silva MA

Idioma: Español
Referencias bibliográficas: 32
Paginas: 227-223
Archivo PDF: 56.46 Kb.

RESUMEN

Antecedentes: Existe una asociación aún no conocida entre niveles altos de RNA VIH-1 y la nefropatía asociada a VIH (NA VIH). También es poco conocida la relación entre niveles de RNA VIH-1 y la enfermedad glomerular asociada a VIH. Objetivo: Determinar la relación entre niveles altos de RNA VIH-1 y la presencia de alteraciones en el rango de filtración glomerular (RFG), en pacientes con infección por VIH. Material y métodos: Se estudiaron prospectivamente 198 pacientes seropositivos para VIH. Se formaron 3 grupos: 53 pacientes con RFG anormal (grupo 1); 48 con proteinuria mayor a 300 mg y menor a 1g en colección de orina de 24 horas, y/o cilindros urinarios (grupo 2); y 87 sin nefropatía (grupo 3). Se comparó la relación de estos grupos con los factores más frecuentemente asociados a nefropatía en pacientes seropositivos para VIH. Resultados: De los factores asociados con nefropatía, solamente los niveles de RNA VIH-1 tuvieron una asociación estadísticamente significativa con un RFG alterado (p=.008). Conclusión: los niveles altos de RNA VIH-1 están asociados a formas iniciales de glomerulopatía asociada a VIH, que no progresan rápidamente a enfermedad renal de estadio final, pero inducen disfunción glomerular, que podría ser sujeta a intervenciones tempranas.

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