Dorantes SM, Cruz CM, Castro HJA, Castañeda CO

Idioma: Español
Referencias bibliográficas: 40
Paginas: 453-459
Archivo PDF: 200.24 Kb.

RESUMEN

Desde hace tiempo la muerte súbita cardíaca y las arritmias ventriculares malig-nas, en sujetos sin cardiopatía estructural demostrable por métodos convenciona-les, ha sido tema de controversia. Las enfermedades eléctricas primarias se hicie-ron equivalentes a enfermedades puramente eléctricas y el término «canalopatía» ha experimentado modificaciones porque a las mutaciones genéticas se añaden alteraciones en algunas proteínas interactuantes y porque existen anomalías es-tructurales como inflamación, fibrosis, adiposis, miocarditis, microaneurismas, au-mento del colágeno, disfunción mecánica y otras, evidenciadas por procedimien-tos diagnósticos más sensibles: el corazón es normal en apariencia pero los mioci-tos no lo son. A la base genética (disfunción iónica) y a la presentación clínica, se integran alteraciones estructurales y se consideran los síndromes de Brugada, de QT largo y de QT corto, como enfermedades orgánico-funcionales, electroanató-micas, con la necesidad de su reclasificación, lo cual es trascendente para estrati-ficar riesgo y adoptar la conducta terapéutica más apropiada.

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