2022, Número 1
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Arch Med 2022; 22 (1)
Valoración de los trastornos neurocognitivos postoperatorios en estudios clínicos: revisión exploratoria
Rojas GDF, Restrepo BM, Múnera GT, Amaya AJJ, Barrera AJ, Restrepo BD
Idioma: Español
Referencias bibliográficas: 29
Paginas: 145-155
Archivo PDF: 314.25 Kb.
RESUMEN
Objetivo: analizar las definiciones empleadas en estudios clínicos para valorar la recuperación
neurocognitiva demorada (RNCd) y los trastornos neurocognitivos menor
y mayor postoperatorio (TNCp).
Materiales y métodos: revisión exploratoria de la
literatura. Se incluyeron estudios clínicos sobre los efectos de la anestesia y cirugía en
términos de trastorno neurocognitivo postoperatorio publicados a partir del año 2013 en
revistas indizadas en Pubmed o Scopus. Se realizó análisis crítico de los métodos de
medición tomando como referencia los criterios planteados en el consenso de nomenclatura.
Resultados: se identificaron 13 estudios, cuatro ensayos clínicos aleatorizados
y nueve estudios observacionales. Solo tres de estos estudios emplearon definiciones
consistentes con el consenso para la RNCd o TNCp. Las principales razones de no
adherencia fueron los tiempos de medición y la no exclusión del delirium u otros trastornos
mentales como explicación del declive cognitivo.
Conclusión: pese a asumir
la nomenclatura de trastornos neurocognitivos perioperatorios, los estudios fallaron en
adherirse a los tiempos y criterios diagnósticos. Proponemos el desarrollo de un Core
Outcome Set como estrategia para avanzar en el propósito de desarrollar evidencia
más homogénea, de alta calidad y relevante para la toma de decisiones clínicas.
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