Arbildo-Vega H, Alay-Baca V, García-Moreno V, Castillo-Cornock T, Giribaldi-Ugáz G, Vásquez-Rodrigo H

Idioma: Español
Referencias bibliográficas: 64
Paginas:
Archivo PDF: 790.21 Kb.

RESUMEN

Introducción: La enfermedad periodontal es un padecimiento inflamatorio, infeccioso y multifactorial crónico, caracterizado por la inflamación de los tejidos blandos periodontales. En estadios avanzados (periodontitis), produce la destrucción progresiva de los tejidos duros periodontales, lo que conduce a la posterior pérdida de dientes, si esta no es tratada.
Objetivo: Determinar la efectividad clínica y radiográfica de las estatinas en el tratamiento de la periodontitis.
Métodos: Se realizó una búsqueda de la literatura hasta abril del 2019, en las bases de datos biomé dicas: PubMed, Embase, SciELO, Science Direct, Scopus, Sistema de información sobre literatura gris en Europa, Literatura Latinoamericana y del Caribe en Ciencias de la Salud, Google Académico y el Registro Central de Ensayos Clínicos Cochrane. Se definieron como criterios de selección de los estudios que fueran ensayos clínicos aleatorizados, con una antigüedad máxima de cinco años y que reportaran los efectos clínicos y radiográficos (profundidad al sondaje, nivel de inserción clínica, índice de placa, índice de sangrado, índice gingival, defecto intraóseo y profundidad del defecto) de las estatinas en el tratamiento de la periodontitis. Se analizó el riesgo de sesgo de los estudios por el Manual Cochrane de revisiones sistemáticas de intervenciones.
Resultados: La estrategia de búsqueda arrojó 19 artículos, de los cuales el 100 % reportó que había diferencia en la profundidad al sondaje, nivel de inserción clínica, índice de placa, índice de sangrado, índice gingival, defecto intraóseo y profundidad del defecto de las estatinas en el tratamiento de la periodontitis.
Conclusiones: La literatura revisada sugiere que el uso de estatinas es efectivo, clínica y radiográficamente, en el tratamiento de la periodontitis.

REFERENCIAS (EN ESTE ARTÍCULO)

1. Petit C, Batool F, Bugueno IM, Schwinté P, Benkirane-Jessel N, Huck O. Contribution of statins towards periodontal treatment: A review. Mediators of Imflammation. 2019;2019:6367402.

2. Kinane DF, Stathopoulou PG, Papapanou PN. Periodontal diseases. Nat Rev Dis Primers. 2017;3:17038.

3. Akram Z, Vohra F, Javed F. Efficacy of statin delivery as an adjunct to scaling and root planning in the treatment of chronic periodontitis: A meta-analysis. J Investig Clin Dent. 2018;9(2):e12304.

4. Holtfreter B, Albandar JM, Dietrich T, Dye BA, Eaton KA, Eke PI, et al. Standards for reporting chronic periodontitis prevalence and severity in epidemiologic studies: Proposed standards from the joint EU/USA periodontal epidemiology working group. J Clin Periodontol. 2015;42(5):407-12.

5. Ambrósio LMB, Rovai ES, Sendyk DI, Holzhausen M, Pannuti CM. Does the adjunctive use of statins provide additional benefits to nonsurgical periodontal treatment? A systematic review and meta-analysis. J Periodontol Res. 2018;53(1):12-21.

6. Shah M, Muley P, Muley A. Are statins worthy for treatment of periodontitis? A systematic review and meta-analysis. Adv Hum Biol. 2017;7(1):8-14.

7. Sinjab K, Zimmo N, Lin GH, Chung MP, Shaikh L, Wang HL. The effect of locally delivered statins on treating periodontal intrabony defects: A systematic review and meta-analysis. J Periodontol. 2017;88(4):357-67.

8. Cekici A, Kantarci A, Hasturk H, Van Dyke TE. Inflammatory and immune pathways in the pathogenesis of periodontal disease. Periodontol 2000. 2014;64(1):57-80.

9. Olsen I, Lambris JD, Hajishengallis G. Porphyromonas gingivalis disturbs host-commensal homeostasis by changing complement function. J Oral Microbiol. 2017;9(1):1340085.

10. Muniz FWMG, Taminski K, Cavagni J, Celeste RK, Weidlich P, Rösing CK. The effect statins on periodontal treatment - a systematic review with meta-analyses and meta-regression. Clin Oral Investig. 2018;22(2):671-87.

11. Akram Z, Abduljabbar T, Kellesarian SV, Abu Hassan MI, Javed F, Vohra F. Efficacy of bisphosphonate as an adjunct to nonsurgical periodontal therapy in the management of periodontal disease. Br J Clin Pharmacol. 2017;83(3):444-54.

12. Alshammari A, Patel J, Al-Hashemi J, Cai B, Panek J, Huck O, et al. Kava-241 reduced periodontal destruction in a collagen antibody primed Porphyromonas gingivalis model of periodontitis. J Clin Periodontol . 2017;44(11):1123-32.

13. Martin-Cabezas R, Davideau JL, Tenenbaum H, Huck O. Clinical efficacy of probiotics as an adjunctive therapy to non-surgical periodontal treatment of chronic periodontitis. J Clin Periodontol . 2016;43(6):520-30.

14. Vohra F, Akram Z, Safii SH, Vaithilingam RD, Ghanem A, Sergis K, et al. Role of antimicrobial photodynamic therapy in the treatment of aggressive periodontitis: a systematic review. Photodiagn Photodyn Ther. 2015;13:139-47.

15. Akram Z, Al-Shareef SA, Daood U, Asiri FY, Shah AH, AlQahtani MA, et al. Bactericidal efficacy of photodynamic therapy against periodontal pathogens in periodontal disease: a systematic review. Photomed Laser Surg. 2016;34(4):137-49.

16. Akram Z, Abduljabbar T, Sauro S, Daood U. Effect of photodynamic therapy and laser aloneas adjunct to scaling and root planing on gingival crevicular fluid inflammatory proteins in periodontal disease: a systematic review. Photodiagnosis Photodyn Ther. 2016;16:142-53.

17. Abduljabbar T, Javed F, Shah A, Samer MS, Vohra F, Akram Z. Role of lasers as an adjunct to scaling and root planing in patients with type 2 diabetes mellitus: a systematic review. Lasers Med Sci. 2017;32(2):449-59.

18. Abduljabbar T, Vohra F, Javed F, Akram Z. Antimicrobial photodynamic therapy adjuvant to non-surgical periodontal therapy in patients with diabetes mellitus: a meta-analysis. Photodiagn Photodyn Ther . 2017;17:138-46.

19. Bertl K, Parllaku A, Pandis N, Buhlin K, Klinge B, Stayropoulos A. The effect of local and systemic statin uses as an adjunct to non-surgical and surgical periodontal therapy - A systematic review and meta-analysis. J Dent. 2017;67:18-28.

20. Jepsen K, Jepsen S. Antibiotics/antimicrobials: systemic and local administration in the therapy of mild to moderately advanced periodontitis. Periodontol 2000. 2016;71(1):82-112.

21. Deas DE, Moritz AJ, Sagun RS Jr, Gruwell SF, Powell CA. Scaling and root planning vs conservative surgery in the treatment of chronic periodontitis. Periodontol 2000. 2016;71(1):128-39.

22. Estanislau IM, Terceiro IR, Lisboa MR, Teles Pde B, Carvalho Rde S, Martins RS, et al. Pleiotropic effects of statins on the treatment of chronic periodontitis. A systematic review. Br J Clin Pharmacol . 2015;79(6):877-85.

23. Meisel P, Kroemer HK, Nauck M, Holtfreter B, Kocher T. Tooth loss, periodontitis, and statins in a population‑based follow‑up study. J Periodontol . 2014;85(6):e160‑8.

24. Martin-Ruiz E, Olry-de-Labry-Lima A, Ocaña-Riola R, Epstein D. Systematic review of the effect of adherence to statin treatment on critical cardiovascular events and mortality in primary prevention. J Cardiovasc Pharmacol Ther. 2018;23(3):200-15.

25. Gelissen IC, McLachlan AJ. The pharmacogenomics of statins. Pharmacol Res. 2014;88:99-106.

26. Mihos CG, Pineda AM, Santana O. Cardiovascular effects of statins, beyond lipid-lowering properties. Pharmacol Res . 2014;88:12-9.

27. Sirtori CR. The pharmacology of statins. Pharmacol Res . 2014;88:3-11.

28. Fong CW. Statin in therapy: understanding their hydrophilicity, lipophilicity, binding to 3-hydroxy-3-methylglutaryl-CoA reductase, ability to cross the blood brain barrier and metabolic stability based on electrostatic molecular orbital studies. Eur J Med Chem. 2014;85:661-74.

29. Margaritis M, Sanna F, Antoniades C. Statins and oxidative stress in the cardiovascular system. Curr Pharm Des. 2017;23(46):7040-7.

30. Whitaker EJ, Alshammari A. Bacteriostatic effect of simvastatin on selected oral Streptococci in vitro. Contemp Clin Dent. 2017;8(1):59-63.

31. Zeiser R. Immune modulatory effects of statins. Immunology. 2018;154(1):69-75.

32. Shah SR, Werlang CA, Kasper FK, Mikos AG. Novel applications of statins for bone regeneration. Natl Sci Rev. 2015;2(1):85‐99.

33. Poston CJ, Pierce TC, Li Y, Brinson CW, Lu Z, Lauer AW, et al. Statin intake is associated with MMP-1 level in gingival crevicular fluid of patients with periodontitis. Oral Dis. 2016;22(5):438-44.

34. Emani S, Gunjiganur GV, Mehta DS. Determination of the antimicrobial activity of simvastatin against periodontal pathogens, Porphyromonas gingivalis and Agregatibacter actinomycetemcomitans: An in vitro study. Contemp Clin Dent . 2014;5(3):377-82.

35. Ting M, Whitaker EJ, Albandar JM. Systematic review of the in vitro effects of statin on oral and perioral microorganisms. Eur J Oral Sci. 2016;124(1):4-10.

36. Kavalipati N, Shah J, Ramakrishan A, Vasnawala H. Pleitropic effects of statins. Indian J Endocrinol Metab. 2015;19(5):554-62.

37. Cicek Ari V, Ilarslan YD, Erman B, Sarkarati B, Tezcan I, Karabulut E, et al. Statins and IL-1β, IL-10 and MPO levels in gingival crevicular fluid: preliminary results. Inflammation. 2016;39(4):1547-57.

38. Zhou H, Xie Y, Baloch Z, Shi Q, Huo Q, Ma T. The effect of atorvastatin, 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor (HMG-CoA), on the prevention of osteoporosis in ovariectomized rabbits. J Bone Miner Metab. 2017;35(3):245-54.

39. Abbayya K, Zope SA, Naduwinmani S, Pisal A, Puthanakar N. Cell-and gene-based therapeutics for periodontal regeneration. Int J Prev Med. 2015;6:110.

40. Özdoğan AI, İlarslan YD, Kösemehmetoğlu K, Akca G, Kutlu HB, Comerdov E, et al. In vivo evaluation of chitosan based local delivery systems for atorvastatin in treatment of periodontitis. Int J Pham. 2018;550(1-2):470-6.

41. Bertl K, Steiner I, Pandis N, Buhlin K, Klinge B, Stavropoulos A. Statins in nonsurgical and surgical periodontal therapy. A systematic review and meta-analysis of preclinical in vivo trials. J Periodontal Res. 2018;53(3):267-87.

42. Urrútia G, Bonfill X. Declaración PRISMA: una propuesta para mejorar la publicación de revisiones sistemáticas y metaanálisis. Med Clin. 2010;135(11):507-11.

43. Higgins JPT, Green S. Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0. The Cochrane Colaboration; 2011. [acceso: 22/06/2019]. Disponible en: Disponible en: https://www.cochrane-handbook.org

44. Pradeep AR, Karvekar S, Nagpal K, Patnaik K, Guruprasad CN, Kumaraswamy KM. Efficacy of locally delivered 1.2% rosuvastatin gel to non-surgical treatment of patients with chronic periodontitis: a randomized, placebo-controlled clinical trial. J Periodontol . 2015;86(6):738-45.

45. Surve SM, Acharya AB, Thakur SL. Efficacy of subgingivally delivered atorvastatin and simvastatin as an adjunct to scaling and root planning. Drug Metab Pers Ther. 2015;30(4):263-9.

46. Pradeep AR, Garg V, Kanoriya D, Singhal S. Platelet-rich fibrin with 1.2% rosuvastatin for treatment of intrabony defects in chronic periodontitis: A randomized controlled clinical trial. J Periodontol . 2016;87(12):1468-73.

47. Pradeep AR, Garg V, Kanoriya D, Singhal S. 1.2% rosuvastatin versus 1.2% atorvastatin gel local drug delivery and redelivery in treatment of intrabony defects in chronic periodontitis: A randomized placebo-controlled clinical trial. J Periodontol . 2016;87(7):756-62.

48. Pradeep AR, Karvekar S, Nagpal K, Patnaik K, Raju A, Singh P. Rosuvastatin 1.2 mg in situ gel combined with 1:1 mixture of autologous platelet-rich fibrin and porous hydroxyapatite bone graft in surgical treatment of mandibular class II furcation defects: A randomized clinical control trial. J Periodontol . 2016;87(1):5-13.

49. Grover HS, Kapoor S, Singh A. Effect of topical simvastatin (1.2 mg) on gingival crevicular fluid interleukin-6, interleukin-8 and interleukin-10 levels in chronic periodontitis - A clinicobiochemical study. J Oral Biol Craniofac Res. 2016;6(2):85-92.

50. Martande SS, Kumari M, Pradeep AR, Singh SP, Suke DK, Guruprasad CN. Platelet-rich fibrin combined with 1.2% atorvastatin for treatment of intrabony defects in chronic periodontitis: A randomized controlled clinical trial. J Periodontol . 2016;87(9):1039-46.

51. Kumari M, Martande SS, Pradeep AR, Naik SB. Efficacy of subgingivally delivered 1.2% atorvastatin in the treatment of chronic periodontitis in patients with type 2 diabetes mellitus: A randomized controlled clinical trial. J Periodontol . 2016;87(11):1278-85.

52. Agarwal S, Chaubey KK, Chaubey A, Agarwal V, Madan E, Agarwal MC. Clinical efficacy of subgingivally delivered simvastatin gel in chronic periodontitis patients. J Indian Soc Periodontol. 2016;20(4):409-16.

53. Zhu L, Fan M, Zhang H. Application of platelet rich fibrin combined with atorvastatin in the regeneration treatment of degree II furcation involvements of mandibular molars. Biomedical research. 2017;28(22):10191-5.

54. Zhu L, Fan M, Zhang H, Li W, She X. Comparison of alendronate sodium gel and simvastatin gel administration in the treatment of mandibular molar furcation involvement. Biomed Res. 2017;28(22):10176-80.

55. Kumari M, Martande SS, Pradeep AR. Subgingivally delivered 1.2% atorvastatin in the treatment of chronic periodontitis among smokers: A randomized, controlled clinical trial. J Investig Clin Dent . 2017;8(2).

56. Pradeep AR, Kanoriya D, Singhal S, Garg V, Manohar B, Chatterjee A. Comparative evaluation of subgingivally delivered 1% alendronate versus 1.2% atorvastatin gel in treatment of chronic periodontitis: A randomized placebo-controlled clinical trial. J Investig Clin Dent . 2017;8(3).

57. Garg S, Pradeep AR. 1.2% rosuvastatin and 1.2% atorvastatin gel local drug delivery and redelivery in the treatment of class II furcation defects: A randomized controlled clinical trial. J Periodontol . 2017;88(3):259-65.

58. Priyanka N, Abhilash A, Saquib S, Malgaonkar N, Kudyar N, Gupta A, et al. Clinical efficacy of subgingivally delivered 1.2 mg simvastatin in the treatment of patients with aggressive periodontitis: A randomized controlled clinical trial. Int J Periodontics Restorative Dent. 2017;37(2):e135-41.

59. Martande SS, Kumari M, Pradeep AR, Singh SP, Kumar D. Comparative evaluation of efficacy of subgingivally delivered 1.2% atorvastatin and 1.2% simvastatin in the treatment of intrabony defects in chronic periodontitis: A randomized controlled trial. J Dent Res Dent Clin Dent Prospects. 2017;11(1):18-25.

60. Gunjiganur VG, Emani S, Mehta DS, Bhandari S. Effect of 1.2% of simvastatin gel as a local drug delivery system on gingival crevicular fluid interleukin-6 & interleukin-8 levels in nonsurgical treatment of chronic periodontitis patients. Arch Oral Biol. 2017;82:55-61.

61. Ranjan R, Patil SR. HRV effect of in-situ application of simvastatin gel in surgical management of osseous defects in chronic periodontitis - A randomized clinical trial. J Oral Craniofac Res. 2017;7(2):113-8.

62. Pankaj D, Sahu I, Kurian IG, Pradeep AR. Comparative evaluation of subgingivally delivered 1.2% rosuvastatin and 1% metformin gel in treatment of intrabony defects in chronic periodontitis: A randomized controlled clinical trial. J Periodontol . 2018;89(11):1318-25.

63. Thylin MR, McConnell JC, Schmid MJ, Reckling RR, Ojha J, Bhattacharyya I, et al. Effects of simvastatin gels on murine calvarial bone. J Periodontol . 2002;73(10):1141-8.

64. Aljudaibi S, Duane B. Do adjunctive statins improve periodontal treatment outcomes in patients with chronic periodontitis? Evid Based Dent. 2019;20:18-9.