Trevethan CS

Idioma: Español
Referencias bibliográficas: 37
Paginas: 171-176
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RESUMEN

El advenimiento de los inhibidores de la convertasa de angiotensina, así como el de los bloqueadores de receptores selectivos de agiotensina AT1 han cambiado, sin lugar a dudas, el panorama del tratamiento de la hipertensión arterial sistémica y el de la insuficiencia cardiaca, pero también su utilidad se ha extendido a la disfunción ventricular izquierda asintomática, al manejo del infarto y postinfarto del miocardio y a diferentes nefropatías, no sólo diabética sino también de otras etiologías, y más aún, su utilidad en la prevención primaria de la cardiopatía coronaria empieza a ser manifiesta. Las principales ventajas de este nuevo grupo de fármacos radica en su relativa inocuidad y su baja producción de efectos indeseables que se tenían con el empleo de otros agentes antihipertensivos. Los inhibidores de los receptores AT1 de angiotensina hoy por hoy no han mostrado ser superiores a los inhibidores de la ECA (aun cuando no son peores), sin embargo son mejor tolerados, y parecen cubrir mayor tiempo de protección farmacológica con dosis únicas. Se requiere de un mayor número de macroestudios con bloqueadores selectivos de los receptores AT1 para conocer su justo lugar en la terapéutica.

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