Escobar CM, Zuluaga A

Idioma: Español
Referencias bibliográficas: 39
Paginas: 231-242
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RESUMEN

Después del descubrimiento de los primeros antimicóticos hace aproximadamente 5 décadas, se ha dado un constante desarrollo de estos agentes terapéuticos.Debido al aumento de resistencia a los antimicóticos, toxicidad, interacciones medicamentosas así como espectro subòptimo, se han desarrollado nuevos agentes: triazoles de segunda generación (voriconazol, posaconazol, ravuconazol, albaconazol), equinocandinas (caspofungina, anidulafungina, micafungina) entre otros.El voriconazol aprobado por la FDA para el tratamiento de la aspergillosis invasiva resistente a otras terapias. Las equinocandinas con alta selectividad contra la Candida spp., Aspergillus spp. y Pneumocistis carinii.En dermatología se ha usado con éxito el voriconazol para el tratamiento de dermatofitos, micosis profundas causadas por Fonseca pedrosoi, Paecilomyces lilacinus y Scedosporium apiospemum. El ravuconazol también ha sido usado con buen resultado para onicomicosis causada por dermatofitos y la caspofungina para el tratamiento de Aspergillus resistente a la anfotericina B.

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