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2001, Número 6

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Salud Mental 2001; 24 (6)


Perspectiva neurobiológica de la esquizofrenia

Graff-Guerrero A, Apiquian R, Fresán A, García-Anaya M

Idioma: Español
Referencias bibliográficas: 48
Paginas: 36-42
Archivo PDF: 216.65 Kb.


RESUMEN

En esta revisión se examinan los diversos sistemas bioquímicos relacionados con la esquizofrenia, así como sus interacciones a fin de explicar su fisiopatología, ya que hasta ahora se ha intentado partir de una sola teoría bioquímica para explicar la génesis de la esquizofrenia. La dopamina es uno de los principales neurotransmisores involucrados en la génesis de la esquizofrenia. El planteamiento actual del funcionamiento dopaminérgico radica en la presencia de un estado hipodopaminérgico en la corteza prefrontal y un estado hiperdopaminérgico, principalmente en los ganglios basales. En esta revisión se examinan los diversos sistemas bioquímicos relacionados con la esquizofrenia, así como sus interacciones a fin de explicar su fisiopatología, ya que hasta ahora se ha intentado partir de una sola teoría bioquímica para explicar la génesis de la esquizofrenia. La dopamina es uno de los principales neurotransmisores involucrados en la génesis de la esquizofrenia. El planteamiento actual del funcionamiento dopam inérgico radica en la presencia de un estado hipodopaminérgico en la corteza prefrontal y un estado hiperdopaminérgico, principalmente en los ganglios basales.


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